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Neuroimaging and Physiological Evidence for Involvement of Glutamatergic Transmission in Regulation of the Striatal Dopaminergic System
https://repo.qst.go.jp/records/45439
https://repo.qst.go.jp/records/45439df796491-fa1b-4c7e-b494-afdda35fc846
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-03-12 | |||||
| タイトル | ||||||
| タイトル | Neuroimaging and Physiological Evidence for Involvement of Glutamatergic Transmission in Regulation of the Striatal Dopaminergic System | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Tokunaga, Masaki
× Tokunaga, Masaki× Seneca, Nicholas× Shin, Ryong-Moon× Maeda, Jun× Obayashi, Shigeru× Okauchi, Takashi× Nagai, Yuji× Zhang, Ming-Rong× Nakao, Ryuji× Ito, Hiroshi× Innis, Rb× Halldin, Christer× Suzuki, Kazutoshi× Higuchi, Makoto× Suhara, Tetsuya× 徳永 正希× セネカ ニコラス× 辛 龍文× 前田 純× 大林 茂× 岡内 隆× 永井 裕司× 張 明栄× 伊藤 浩× ハルディン クリスタ× 鈴木 和年× 樋口 真人× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Aberrant neurotransmissions via glutamate and dopamine receptors have been the focus of biomedical research on the molecular basis of psychiatric disorders, but the mode of their interaction is yet to be uncovered. In this study, we demonstrated the pharmacological reversal of methamphetamine-stimulated dopaminergic overflow by suppression of group I metabotropic glutamate (mGlu) receptor in living primates and rodents. In vivo positron emission tomography (PET) was conducted on cynomolgus monkeys and rats using a full agonistic tracer for dopamine D2/3 receptor, [ 11C]MNPA [(R)-2-11CH3O-N-n-propylnorapomorphine], and fluctuation of kinetic data resulting from anesthesia was avoided by scanning awake subjects. Excessive release of dopamine induced by methamphetamine and abolishment of this alteration by treatment with an antagonist of group I mGlu receptors, 2-methyl-6-(phenylethynyl)pyridine (MPEP), were measured in both species as decreased binding potential because of increased dopamine and its recovery to baseline levels, respectively. Counteraction of MPEP to the methamphetamine-induced dopamine spillover was also supported neurochemically by microdialysis of unanesthetized rat striatum. Moreover, patch-clamp electrophysiological assays using acute brain slices prepared from rats indicated that direct targets ofMPEPmechanistically involved in the effects of methamphetamine are present locally within the striatum. Because MPEPalone did not markedly alter the baseline dopaminergic neurotransmission according to our PET and electrophysiological data, the present findings collectively extend the insights on dopamine– glutamate cross talk from extrastriatal localization of responsible mGlu receptors to intrastriatal synergy and support therapeutic interventions in case of disordered striatal dopaminergic status using group I mGlu receptor antagonists assessable by in vivo imaging techniques. |
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| 書誌情報 |
The Journal of Neuroscience 巻 29, 号 6, p. 1887-1896, 発行日 2009-02 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0270-6474 | |||||
