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Adenosine A1 receptors using 8-dicyclopropylmethyl-1-[11C]methyl-3-propylxanthine PET in Alzheimer's disease
https://repo.qst.go.jp/records/45402
https://repo.qst.go.jp/records/454027a6ac348-ad72-4286-825d-df0495d1876c
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-01-20 | |||||
| タイトル | ||||||
| タイトル | Adenosine A1 receptors using 8-dicyclopropylmethyl-1-[11C]methyl-3-propylxanthine PET in Alzheimer's disease | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fukumitsu, Nobuyoshi
× Fukumitsu, Nobuyoshi× Ishii, Kenji× Kimura, Yuichi× Oda, Keiichi× Hashimoto, Masaya× Suzuki, Masahiko× Ishiwata, Kiichi× 石井 賢二× 木村 裕一× 織田 圭一× 石渡 喜一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective: Adenosine is an endogenous modulator ofsynaptic functions in the central nervous system. The effects of adenosine are mediated by at least four adenosinereceptor subtypes. Decreased density of adenosine A1receptors, which is a major subtype adenosine receptor in the hippocampus, has been reported in vitro in Alzheimer's disease. We evaluated adenosine A1 receptor in the brain of elderly normal subjects and patients with Alzheimer's disease (n = 8 and 6, respectively),using positron emission tomography (PET) and 8-dicyclopropylmethyl-1-[11C]methyl-3-propylxanthine ([11C]MPDX). \nMethods: A 60-min PET scan with [11C]MPDX wasperformed. The patients with Alzheimer's disease also underwent PET with [18F]fl uorodeoxyglucose (FDG). The binding potential of [11C]MPDX was quantitativelycalculated in the regions of interest (ROIs) placed on the frontal, medial frontal, temporal, medial temporal, parietal, and occipital cortices, striatum, thalamus, cerebellum, and pons. Statistical parametric mapping (SPM2) was used for analysis of [11C]MPDX and FDG-PET. \nResults: In the ROI-based analysis, the binding potential of [11C]MPDX in patients with Alzheimer's disease was signifi cantly lower in the temporal and medial temporal cortices and thalamus than that in elderly normal subjects(P = 0.038, 0.028, and 0.039, respectively). SPM analysis also showed signifi cant decreased binding potential in the temporal and medial temporal cortices and thalamus in patients with Alzheimer's disease. FDG uptake was signifi cantly decreased in the temporoparietal cortex and posterior cingulate gyrus. \nConclusions: Decreased binding of [11C]MPDX in patients with Alzheimer's disease was detected in temporal and medial temporal cortices and thalamus. This pattern possibly differed from the hypometabolism pattern of FDG. [11C]MPDX PET is valuable for the detection of degeneration in the temporal and medial temporal cortices and corticothalamic transmission, and may provide a different diagnostic tool from FDG-PET in brain disorders such as Alzheimer's disease. |
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| 書誌情報 |
Annals of Nuclear Medicine 巻 22, 号 10, p. 841-847, 発行日 2009-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0914-7187 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s12149-008-0185-5 | |||||
