WEKO3
アイテム
Metabolism and Paradoxical Effects of Arsenic: Carcinogenesis and Anticancer
https://repo.qst.go.jp/records/45350
https://repo.qst.go.jp/records/453501ccc4542-649a-4772-bae7-51798d34034e
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-12-18 | |||||
| タイトル | ||||||
| タイトル | Metabolism and Paradoxical Effects of Arsenic: Carcinogenesis and Anticancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Cui, Xing
× Cui, Xing× Kobayashi, Yayoi× Akashi, Makoto× Okayasu, Ryuichi× 崔 星× 明石 真言× 岡安 隆一 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Arsenic, a known human carcinogen, can induce tumors of the skin, urinary bladder, liver and lung etc.. On the other hand, arsenic is also a novel promising anticancer agent, and can be used effectively to treat acute promyelocytic leukemia (APL) and some other tumors. These paradoxical effects of arsenic not only result from direct or indirect influences on the genetic and epigenetic levels, but are also closely correlated with unique arsenic metabolism. This article reviews our recent studies as well as other reports on arsenic metabolism and epigenetic changes of DNA methylation during its metabolism. We also summarize the clinical use of arsenic trioxide (As2O3) to date and discuss new therapeutic strategies such as concurrent arsenic-radiation therapy to achieve local tumor control and enhance the radiosensitivity of solid tumors. | |||||
| 書誌情報 |
Current Medicinal Chemistry 巻 15, 号 22, p. 2293-2304, 発行日 2008-09 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0929-8673 | |||||
