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Histone H2AX Phosphorylation Independent of ATM after X-irradiation in Mouse Liver and Kidney in situ
https://repo.qst.go.jp/records/45282
https://repo.qst.go.jp/records/45282dc5503ea-2f36-4676-b373-047e406d232a
| アイテムタイプ | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2008-10-07 | |||||
| タイトル | ||||||
| タイトル | Histone H2AX Phosphorylation Independent of ATM after X-irradiation in Mouse Liver and Kidney in situ | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Koike, Manabu
× Koike, Manabu× Mashino, Minako× Sugasawa, Jun× Koike, Aki× 小池 学× 増野 美奈子× 菅澤 純× 小池 亜紀 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Histone H2AX undergoes phosphorylation at Ser-139 (gamma-H2AX) rapidly in response to DNA double-strand breaks (DSBs) induced by ionizing radiation. The post-translational modification of H2AX plays a central role in responses to radiation, including the repair of DSBs. Although ataxia telangiectasia mutated (ATM) kinase phosphorylates Ser-139 of H2AX in vitro, the post-translational modification pattern and the modifier of H2AX in organs in vivo are not yet well understood. In this study, we detected phosphorylation of H2AX at Ser-139 in cells of the mouse ear, liver, and kidney after X-irradiation. Moreover, the phosphorylation of H2AX was regulated depending on not only the cell type, but also the organ type and the localization of a cell type in an organ. Following X-irradiation, H2AX was phosphorylated in the liver and kidney of ATM gene knockout mice, suggesting that ATM kinase is not essential for phosphorylation of H2AX in these organs after X-irradiation in vivo. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 49, 号 4, p. 445-449, 発行日 2008-07 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
