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アイテム
Relationship between Baseline Cerebral Blood Flow and Vascular Responses to Changes in PaCO2 Measured by Positron Emission Tomography in Humans:Implication of Inter-individual Variations of Cerebral Vascular Tone
https://repo.qst.go.jp/records/45264
https://repo.qst.go.jp/records/452640c622e02-9569-4793-95a5-9d5c1e5398ad
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-09-16 | |||||
| タイトル | ||||||
| タイトル | Relationship between Baseline Cerebral Blood Flow and Vascular Responses to Changes in PaCO2 Measured by Positron Emission Tomography in Humans:Implication of Inter-individual Variations of Cerebral Vascular Tone | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ito, Hiroshi
× Ito, Hiroshi× Kanno, Iwao× Masanobu, Ibaraki× Suhara, Tetsuya× Miura, Syuichi× 伊藤 浩× 菅野 巖× 茨木 正信× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | AIM: Inter-individual variations in normal human cerebral blood flow (CBF) at rest condition have been reported. Inter-individual variation of cerebral vascular tone is considered to contribute to this, and several determinants of cerebral vascular tone have been proposed. In the present study, the relationship between CBF and cerebral vascular tone to inter-individual variation at rest condition was investigated using positron emission tomography (PET). METHODS: CBF was measured using PET with H(2) (15)O in each of 20 healthy subjects (20-28 years) under three conditions: at rest (baseline), during hypercapnia and during hypocapnia. The vascular response to change in P(a)CO(2) was calculated as the percentage changes in CBF per absolute change in P(a)CO(2) in response to hypercapnia and hypocapnia. RESULTS: A significant negative correlation between baseline CBF and the vascular response to hypocapnia was observed in the thalamus, temporal cortex, parietal cortex, occipital cortex and cerebral cortex (P < 0.05). A trend towards negative correlation between baseline CBF and the vascular response to hypocapnia was observed in the cerebellum and putamen (P < 0.1). A significant negative correlation between baseline CBF and the vascular response to hypercapnia was observed in the occipital cortex (P < 0.05). No significant correlation was observed between baseline CBF and haemoglobin concentration, and P(a)CO(2). CONCLUSION: These findings support the assumption that cerebral vascular tone might incline towards vasoconstriction and vasodilatation when baseline CBF is low and high between individuals respectively. Although several determinants of cerebral vascular tone have been proposed, the mechanism of such inter-individual differences in cerebral vascular tone is unknown. | |||||
| 書誌情報 |
Acta Physiologica 巻 193, 号 4, p. 325-330, 発行日 2008-08 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1748-1708 | |||||
