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Imaging Brain Vasculature with BOLD Microscopy: MR Detection Limits Determined by in Vivo Two-Photon Microscopy.
https://repo.qst.go.jp/records/45209
https://repo.qst.go.jp/records/45209e4edaea7-77e5-403e-9147-f9e081170757
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-06-26 | |||||
| タイトル | ||||||
| タイトル | Imaging Brain Vasculature with BOLD Microscopy: MR Detection Limits Determined by in Vivo Two-Photon Microscopy. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Park, Sung-Hong
× Park, Sung-Hong× Masamoto, Kazuto× Kanno, Iwao× Kim, Seong-Gi× et.al× 正本 和人× 菅野 巖 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Rat brain vasculature was imaged at 9.4T with blood oxygenation level-dependent (BOLD) microscopy. Data were acquired without exogenous contrast agent in <35 min using 3D gradient- echo imaging with 78-m isotropic resolution. Detailed vascular patterns including intracortical veins and some branches were observed in simple magnitude-contrast data acquired at an experimentally optimized echo time. The venous origin of the dark patterns was confirmed by oxygenation-dependent studies, and when the systemic arterial oxygen saturation level was <80% BOLD microscopy revealed additional intracortical vessels presumed to be of arterial origin. Quantification shows a decrease of intracortical venous density with depth. The full width at half-minimum intensity was 90-190 m for most intracortical venous vessels identifiable by BOLD venography. Since actual diameters are not directly quantifiable by BOLD, we also measured diameter-dependent intracortical venous density in vivo by two-photon excitation fluorescent microscopy. Density comparisons between the two modalities, along with computer simulations, show that venous vessels as small as 16-30 m diameter are detectable with 9.4T BOLD icroscopy under our experimental conditions. |
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| 書誌情報 |
Magnetic Resonance in Medicine 巻 59, 号 4, p. 855-865, 発行日 2008-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0740-3194 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/mrm.21573 | |||||
