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  1. 原著論文

Enhanced dopamine release by nicotine in cigarette smokers:a duuble-blind,randomized,placebo-controlled pilot study

https://repo.qst.go.jp/records/45148
https://repo.qst.go.jp/records/45148
8ad12a9f-b1df-43bb-9efa-eb571d9b91d6
Item type 学術雑誌論文 / Journal Article(1)
公開日 2008-05-07
タイトル
タイトル Enhanced dopamine release by nicotine in cigarette smokers:a duuble-blind,randomized,placebo-controlled pilot study
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Takahashi, Hidehiko

× Takahashi, Hidehiko

WEKO 448330

Takahashi, Hidehiko

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Fujimura, Yota

× Fujimura, Yota

WEKO 448331

Fujimura, Yota

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Hayashi, Mika

× Hayashi, Mika

WEKO 448332

Hayashi, Mika

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Takano, Harumasa

× Takano, Harumasa

WEKO 448333

Takano, Harumasa

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Okubo, Yoshiro

× Okubo, Yoshiro

WEKO 448334

Okubo, Yoshiro

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Kanno, Iwao

× Kanno, Iwao

WEKO 448335

Kanno, Iwao

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Ito, Hiroshi

× Ito, Hiroshi

WEKO 448336

Ito, Hiroshi

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Suhara, Tetsuya

× Suhara, Tetsuya

WEKO 448337

Suhara, Tetsuya

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et.al

× et.al

WEKO 448338

et.al

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高橋 英彦

× 高橋 英彦

WEKO 448339

en 高橋 英彦

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藤村 洋太

× 藤村 洋太

WEKO 448340

en 藤村 洋太

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林 海香

× 林 海香

WEKO 448341

en 林 海香

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高野 晴成

× 高野 晴成

WEKO 448342

en 高野 晴成

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大久保 善朗

× 大久保 善朗

WEKO 448343

en 大久保 善朗

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菅野 巖

× 菅野 巖

WEKO 448344

en 菅野 巖

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伊藤 浩

× 伊藤 浩

WEKO 448345

en 伊藤 浩

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須原 哲也

× 須原 哲也

WEKO 448346

en 須原 哲也

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抄録
内容記述タイプ Abstract
内容記述 Previous studies of smoking on dopamine release in humans were investigated only in smokers. Using nicotine gum, we examined the effect of nicotine on dopamine release in smokers and non-smokers and its relation to the degree of nicotine dependence. Smokers and non-smokers participated in a double-blind, randomized, placebo-controlled cross-over study. They participated in two PET measurements with [11C]raclopride, in which they received either nicotine or placebo. Changes in [11C]raclopride non-displaceable binding potential (BPND) following nicotine administration were quantified. Smokers showed significant decrease in BP in the striatum following nicotine administration, but non-smokers did not show such a decrease. The BPND difference between the two scanning sessions was correlated with the degree of nicotine dependence. The BPND difference might reflect enhanced dopamine release in smokers and the reinforced effect of nicotine. These data suggest the feasibility of our gum method as well as the importance of the degree of dependence in future studies of the nicotine effect on the dopamine system.
書誌情報 The International Journal of Neuropsychopharmacology

巻 11, 号 3, p. 413-417, 発行日 2008-05
ISSN
収録物識別子タイプ ISSN
収録物識別子 1461-1457
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