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Earty development of the cerebellum in teleost fishes: A study based on gene expression patterns and histology in the medaka embryo
https://repo.qst.go.jp/records/45141
https://repo.qst.go.jp/records/45141ef1d8067-46fe-44ef-9a87-41f212fffbe4
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-04-21 | |||||
| タイトル | ||||||
| タイトル | Earty development of the cerebellum in teleost fishes: A study based on gene expression patterns and histology in the medaka embryo | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ishikawa, Yuuji
× Ishikawa, Yuuji× Yasuda, Takako× Kage, Takahiro× Takashima, Shigeo× Yoshimoto, Masami× Yamamoto, Naoyuki× Maruyama, Kouichi× Takeda, Hiroyuki× Itou, Hironobu× 石川 裕二× 保田 隆子× 景 崇洋× 丸山 耕一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The cerebellar structures of the teleost are markedly different from those of other vertebrates. The cerebellum continues rostrally into the midbrain ventricle, forming the valvula cerebelli, only in ray-finned fishes among vertebrates. To analyze the ontogenetic processes that underlie this morphological difference, we examined the early development of the cerebellar regions, including the isthmus(mid/hindbrain boundary, MHB), of medaka (Oryzias latipes), by histology and in situ hybridization using two gene(wnt1 and fgf8) probes. Isthmic wnt1 was expressed stably in the caudalmost mesencephalic region in the neural tube at all developmental stages examined, defining molecularly the caudal limit of the mesencephalon. The wnt1-positive mesencephalic cells became located rostrally to the isthmic constriction at Iwamatsu's stages 25-26. Isthmic fgf8 expression changed dynamically and became restricted to the rostralmost metencephalic region at stage 24. The rostralmost part (prospective valvula cerebelli) of the fgf8-positive rostral metencephalon protruded rostrally into the midbrain ventricle bypassing the isthmic constriction at stages 25-26. Thus, the isthmic constriction shifted caudally with respect to the molecularly defined MHB at stages 25-26. Paired cerebellar primordia were formed from the alar plates of the fgf8-positive rostral metencephalon and the fgf8-negative caudal metencephalon in the medaka neural tube. Our results show that cerebellar development differs between teleosts and murines: Both the rostral and caudal metencephalic alar plates develop into the cerebellum in medaka, whereas only the caudal metencephalic alar plate develops into the cerebellum and the rostral one is reduced into a thin membrane in murines. |
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| 書誌情報 |
Zoological Science 巻 25, 号 4, p. 407-418, 発行日 2008-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0289-0003 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.2108/zsj.25.407 | |||||
