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Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans
https://repo.qst.go.jp/records/45124
https://repo.qst.go.jp/records/451249d593f7e-e877-431c-b809-9139384a76df
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-03-25 | |||||
| タイトル | ||||||
| タイトル | Ionizing radiation downregulates ASPM, a gene responsible for microcephaly in humans | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fujimori, Akira
× Fujimori, Akira× Bing, Wang× Suetomi, Katsutoshi× Sekine, Emiko× Yu, Dong× Kato, Takamitsu× Takahashi, Sentaro× Okayasu, Ryuichi× et.al× 藤森 亮× 王 冰× 末冨 勝敏× 関根 絵美子× 于 冬× 加藤 宝光× 高橋 千太郎× 岡安 隆一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Microcephaly is a malformation associated with in utero exposed atomic bomb survivors and can be induced in mice by fetal exposure to ionizing radiation (IR). The pathogenesis of IR-induced microcephaly, however, has not been fully understood. Our analyses of high-coverage expression profiling (HiCEP) demonstrated that the abnormal spindle-like microcephaly associated gene (ASPM) was down-regulated in irradiated human diploid fibroblasts. ASPM was recently reported as the causative gene for MCPH-5, the most common type of congenital microcephaly in humans. Here we show that the expression of the Aspm gene was significantly reduced by IR in various human and murine cells. Additionally, Aspm was found downregulated in the irradiated fetal mouse brain, particularly in the ventricular zones. A similar suppression was observed in the irradiated neurosphere cultures. This is the first report suggesting that the suppression of Aspm by IR could be the initial molecular target leading to the future microcephaly formation. | |||||
| 書誌情報 |
Biochemical and Biophysical Research Communications 巻 369, 号 3, p. 953-957, 発行日 2008-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0006-291X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.bbrc.2008.02.149 | |||||
