WEKO3
アイテム
Neurobehavioral protection by single dose l-deprenyl against MPTP-induced parkinsonism in common marmosets
https://repo.qst.go.jp/records/45091
https://repo.qst.go.jp/records/450911bb27fd9-9ff0-408f-8bc3-fbabb38acdc3
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-02-07 | |||||
| タイトル | ||||||
| タイトル | Neurobehavioral protection by single dose l-deprenyl against MPTP-induced parkinsonism in common marmosets | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Andou, Kiyoshi
× Andou, Kiyoshi× Maeda, Jun× Inaji, Motoki× Okauchi, Takashi× Obayashi, Shigeru× Higuchi, Makoto× Suhara, Tetsuya× et.al× 安東 潔× 前田 純× 稲次 基希× 岡内 隆× 大林 茂× 樋口 真人× 須原 哲也 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objective Establishment of preclinical method evaluating behavioral protective actions of drugs for Parkinsons disease was attempted by using l-deprenyl (DEP) as a reference drug in MPTP-treated common marmosets. Methods Fifteen marmosets received MPTP at 2 mg/kg, subcutaneously (s.c.) per day for 3 consecutive days. To these marmosets, intragastric (i.g.) administration of DEP at 10 mg/kg was pretreated 2 hrs before each MPTP administration in DEP3 group and pretreated only in the 1st MPTP administration day in DEP1 group. As a control, distilled water (DW) was pretreated before each MPTP administration (n=5 for each of 3 groups). Results In DW group, decreased daily activity counts and increased dysfunction scores were persistently observed for 3 weeks after MPTP. In DEP groups, the similar changes of both levels to those in DW group were temporally observed after MPTP for several days and then the values recovered to the pre-MPTP levels. The results of autoradiography performed after above behavioral observations indicated that markedly lower bindings of [11C]PE2I (ligand for dopamine transporters) were observed at the striatum of DW group marmoset as compared with the striatum of additionally prepared MPTP-free marmoset (n=5). The bindings in DEP groups were almost the same as in the MPTP-free marmoset brains. Conclusion The present preclinical methods using continuous recording of activity of marmosets in their living cages and autoradiography using dopmamine transporter ligand might be sensitive for detecting protective actions of drugs for Parkinsons disease. |
|||||
| 書誌情報 |
Psychopharmacology 巻 195, 号 4, p. 509-516, 発行日 2008-01 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0033-3158 | |||||
