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Monitoring the irradiation field of 12C and 16O SOBP beams using positron emitters produced through projectile fragmentation reactions
https://repo.qst.go.jp/records/45073
https://repo.qst.go.jp/records/4507305f4e0e1-78fd-421f-b13a-6178e726784e
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-01-09 | |||||
| タイトル | ||||||
| タイトル | Monitoring the irradiation field of 12C and 16O SOBP beams using positron emitters produced through projectile fragmentation reactions | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Inaniwa, Taku
× Inaniwa, Taku× Kohno, Toshiyuki× Tomitani, Takehiro× Satou, Shinji× 稲庭 拓× 河野 俊之× 富谷 武浩× 佐藤 眞二 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In order to effectively utilize the prominent properties of heavy ions in radiotherapy, it is important to evaluate both the position of the field irradiated with incident ions and the absorbed dose distribution in a patient's body. One of the methods for this purpose is the utilization of the positron emitters produced through the projectile fragmentation reactions of stable heavy ions with target nuclei. In heavy-ion therapy, spread-out Bragg peak (SOBP) beams are used to achieve uniform biological dose distributions in the whole tumor volume. Therefore, in this study, we designed SOBP beams of 30 and 50 mm waterequivalent length (mmWEL)in width for 12Cand 16O, and carried out irradiation experiments using them. Water, polyethylene and polymethyl methacrylate were selected as targets to simulate a human body. Pairs of annihilation gamma rays were detected by means of a limited-angle positron camera for 500 s, and annihilation gamma-ray distributions were obtained. The maximum likelihood estimation (MLE) method was applied to the detected distributions for evaluating the positions of the distal and proximal edges of the SOBP in a target. The differences between the positions evaluated with the MLE method and those derived from the measured dose distributions were less than 1.7 mm and 2.5 mm for the distal and the proximal edge, respectively, in all irradiation conditions. When the positions of both edges are determined with the MLE method, the most probable shape of the dose distribution in a target can be estimated simultaneously. The close agreement between the estimated and the measured distributions implied that the shape of the dose distribution in an irradiated target could be evaluated from the detected annihilation gamma-ray distribution. |
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| 書誌情報 |
Physics in Medicine and Biology 巻 53, 号 3, p. 529-542, 発行日 2008-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0031-9155 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1088/0031-9155/53/3/002 | |||||
