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MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis
https://repo.qst.go.jp/records/45041
https://repo.qst.go.jp/records/450410bdea1e5-ae6b-4489-b59e-e2b0aa2bb7c0
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-12-05 | |||||
| タイトル | ||||||
| タイトル | MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sakamoto, Katsumi
× Sakamoto, Katsumi× Tominaga, Yohei× Yamauchi, Kazumi× Nakatsu, Yoshimichi× Sakumi, Kunihiko× Yoshiyama, Kaoru× Egashira, Akinori× Kura, Shinobu× Yao, Takashi× Tsuneyoshi, Masasumi× Maki, Hisaji× Nakabeppu, Yusaku× Tsuzuki, Teruhisa× 山内 一己× 恒吉 正澄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | MUTYH is a mammalian DNA glycosylase that initiates base excision repair by excising adenine opposite 8-oxoguanine and 2-hydroxyadenine opposite guanine, thereby preventing G:C to T:A transversion caused by oxidative stress. Recently, biallelic germ-line mutations of MUTYH have been found in patients predisposed to a recessive form of hereditary multiple colorectal adenoma and carcinoma with an increased incidence of G:C to T:A somatic mutations in the APC gene. In the present study, a systematic histologic examination revealed that more spontaneous tumors had developed in MUTYH-null mice (72 of 121; 59.5%) than in the wild type (38 of 109; 34.9%). The increased incidence of intestinal tumors in MUTYH-null mice (11 tumors in 10 of 121 mice) was statistically significant compared with the wild type (no intestinal tumors in 109 mice). Two adenomas and seven adenocarcinomas were observed in the small intestines, and two adenomas but no carcinomas were found in the colons. In MUTYH-null mice treated with KBrO(3), the occurrence of small intestinal tumors dramatically increased. The mean number of polyps induced in the small intestines of these mice was 61.88 (males, 72.75; females, 51.00), whereas it was 0.85 (males, 0.50; females, 1.00) in wild-type mice. The tumors developed predominantly in the duodenum and in the upper region of the (jejunum) small intestines. We conclude that MUTYH suppresses spontaneous tumorigenesis in mammals, thus providing experimental evidence for the association between biallelic germ-line MUTYH mutations and a recessive form of human hereditary colorectal adenoma and carcinoma. | |||||
| 書誌情報 |
Cancer Research 巻 67, 号 14, p. 6599-6604, 発行日 2007-07 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0008-5472 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://cancerres.aacrjournals.org/cgi/content/full/67/14/6599 | |||||
| 関連名称 | http://cancerres.aacrjournals.org/cgi/content/full/67/14/6599 | |||||
