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Dynamic change of histone H2AX phosphorylation independent of ATM and DNA-PK in mouse skin in situ.
https://repo.qst.go.jp/records/45026
https://repo.qst.go.jp/records/450261dacdd5a-eec3-4fb2-b148-8056915b74c2
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-11-21 | |||||
| タイトル | ||||||
| タイトル | Dynamic change of histone H2AX phosphorylation independent of ATM and DNA-PK in mouse skin in situ. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Koike, Manabu
× Koike, Manabu× Mashino, Minako× Sugasawa, Jun× Koike, Aki× 小池 学× 増野 美奈子× 菅澤 純× 小池 亜紀 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Histone H2AX undergoes phosphorylation on Ser 139 (gamma-H2AX) rapidly in response to DNA double-strand breaks induced by exogenous stimuli, such as ionizing radiation. However, the endogenous phosphorylation pattern and modifier of H2AX remain unclear. Here we show that H2AX is regulated physically at the level of phosphorylation at Ser139 during a hair cycle in the mouse skin. In anagen hair follicles, gamma-H2AX-positive cells were observed in the outer root sheath (ORS) and hair bulb in a cycling inferior region but not in a permanent superficial region. In telogen hair follicles, gamma-H2AX-positive cells were only detected around the germ cell cap. In contrast, following X-irradiation, gamma-H2AX was observed in various cell types including the ORS cells in the permanent superficial region. Furthermore, gamma-H2AX-positive cells were detected in the skin of mice lacking either ATM or DNA-PK, suggesting that these kinases are not essential for phosphorylation in vivo. | |||||
| 書誌情報 |
Biochemical and Biophysical Research Communications 巻 363, 号 4, p. 1009-12, 発行日 2007-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0006-291X | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBK-4PT1FKS-2&_user=1015400&_coverDate=11%2F30%2F2007&_alid=639688494&_rdoc=1&_fmt=full&_orig=search&_cdi=6713&_sort=d&_docanchor=&view=c&_ct=4&_acct=C000050364&_version=1&_urlVersion=0&_userid=1015400&md5=769a556a07347bba4964fce3f8b5a0e6 | |||||
| 関連名称 | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WBK-4PT1FKS-2&_user=1015400&_coverDate=11%2F30%2F2007&_alid=639688494&_rdoc=1&_fmt=full&_orig=search&_cdi=6713&_sort=d&_docanchor=&view=c&_ct=4&_acct=C000050364&_version=1&_urlVersion=0&_userid=1015400&md5=769a556a07347bba4964fce3f8b5a0e6 | |||||
