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Mutant analyses reveal different functions of fgfr1 in medaka and zebrafish despite conserved ligand-receptor relationships
https://repo.qst.go.jp/records/44996
https://repo.qst.go.jp/records/44996468c547e-63fd-4d3d-8947-1be13ccf9ce1
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-10-10 | |||||
| タイトル | ||||||
| タイトル | Mutant analyses reveal different functions of fgfr1 in medaka and zebrafish despite conserved ligand-receptor relationships | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yokoi, Hayato
× Yokoi, Hayato× Shimada, Atsuko× Carl, Matthias× Takashima, Shigeo× Kobayashi, Daisuke× Narita, Takanori× Jindou, Tomoko× Kimura, Tetsuaki× Kitagawa, Tadao× Kage, Takahiro× Sawada, Atsushi× Naruse, Kiyoshi× Asakawa, Shuichi× Shimizu, Nobuyoshi× Mitani, Hiroshi× Shima, Akihiro× Tsutsumi, Makiko× Hori, Hiroshi× Wittbrodt, Joachim× Saga, Yumiko× Ishikawa, Yuuji× Araki, Kazuo× Takeda, Hiroyuki× 景 崇洋× 三谷 啓志× 石川 裕二 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Medaka (Oryzias latipes) is a small freshwater teleost that provides an excellent developmental genetic model complementary to zebrafish. Our recent mutagenesis screening using medaka identified headfish (hdf) which is characterized by the absence of trunc and tail structures with nealy normal head including the midbrai-hindbrain boundary (MHB).Positional-condidate clodidate cloning revealed that the hdf mutation causes a functionally null form of fgfr1. The fgfr1 hdf is thus the first fgf receptor mutant in fish. Although FGF signaling has been implicated in mesoderm induction, mesoderm is induced normallu in the fgfr1 mutant, but subsequently, mutant embryos fail to maintain the mesoderm, leading to defects in mesoderm derivatives, especially in trunk and tail. Furthermore, we found that morpholino knockdown of medaka fgf8 resulted in a phenotype identical to the fgfr1 hdf mutant, suggesting that like its mouse counterpart, Fgf8 is a major ligand for fgfr1 in medaka early embryogenesis. Intrigungly, Fgf8 and Fgfr1 in zebrafish are also suggested to form a major ligand-receptor pair, but their function is much devirged, as the zebrafish fgfr1 morphant and zebrafish fgf8 mutant acerebellar (ace) only fail to develop the MHB, but develop nearly unaffected trunk and tail. | |||||
| 書誌情報 |
Developmental Biology 巻 304, 号 1, p. 326-337, 発行日 2007-04 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0012-1606 | |||||
