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Phenotypic Analysis of a Novel chordin Mutant in Medaka
https://repo.qst.go.jp/records/44995
https://repo.qst.go.jp/records/44995b7c90c7a-b526-4e76-9b6c-6c7659a1a337
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-10-10 | |||||
| タイトル | ||||||
| タイトル | Phenotypic Analysis of a Novel chordin Mutant in Medaka | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takashima, Shigeo
× Takashima, Shigeo× Shimada, Atsuko× Kobayashi, Daisuke× Yokoi, Hayato× Narita, Takanori× Jindou, Tomoko× Kage, Takahiro× Kitagawa, Tadao× Kimura, Tetsuaki× Sekimizu, Yasunobu× Miyake, Akimitsu× H.E., Setiamarga Davin× Murakami, Ryouhei× Tsuda, Sachiko× Ooki, Shinya× Kakihara, Ken× Hojo, Motoki× Naruse, Kiyoshi× Mitani, Takashi× Shima, Akihiro× Ishikawa, Yuuji× Araki, Kazuo× Sagara, Yumiko× Takeda, Hiroyuki× 景 崇洋× 石川 裕二 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We have isolated and characterized a ventralized mutant in medaka (the Japanese killifish; Oryzias latipes), which turned out to have a mutation in the chordin gene. The mutant exhibits ventralization of the body axis, malformation of axial bones, over-bifurcation of yolk sac blood vessels, and laterality defects in internal organs. The mutant exhibits veriability of phenotypes, depending on the culture temperature, from embryos with a slightly ventralized phenotype to those without any head and trunk structures. Taking advantages of these variable and severe phenotypes, we analyzed the role of Chordin-dependent tissues such as the notochord and Kupffer's vesicle (KV) in the establishment of left-right axis in fish. The results demonstrate that,in the absence of the notochord and KV, the medaka lateral plate mesoderm autonomously and bilaterally expresses spaw gene in a default state. | |||||
| 書誌情報 |
Developmental Dynamics 巻 236, 号 8, p. 2298-2310, 発行日 2007-07 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1058-8388 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/dvdy.21245 | |||||
