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Ferrous Ferric Chloride Stimulates the Proliferation and Differentiation of Cultured Keratinocytes and Melanocytes in the Epidermis of Neonatal Mouse Skin
https://repo.qst.go.jp/records/44994
https://repo.qst.go.jp/records/4499444c6e325-2987-49d2-afa5-dece1e96a653
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-10-06 | |||||
| タイトル | ||||||
| タイトル | Ferrous Ferric Chloride Stimulates the Proliferation and Differentiation of Cultured Keratinocytes and Melanocytes in the Epidermis of Neonatal Mouse Skin | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirobe, Tomohisa
× Hirobe, Tomohisa× 廣部 知久 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Ferrous ferric chloride (FFC) is a special aqueous iron which is a complex of ferrous chloride and ferric chloride and has a function in both oxidation and reduction. FFC is thought to stimulate the cellular function of living organisms. Although FFC is reported to stimulate the function of red blood cells, it has not been determined whether FFC stimulates the function of skin cells. To understand the role of FFC in the function of skin cells, we studied its effects on the proliferation and differentiation of keratinocytes and melanoblasts or melanocytes. FFC was added to a serum-free culture of neonatal mouse epidermal cells and its effects on the proliferation and differentiation of keratinocytes and melanoblasts or melanocytes were investigated. FFC stimulated the proliferation and differentiation of keratinocytes and melanoblasts or melanocytes. The proliferation of keratinocytes and that of melanoblasts or melanocytes was stimulated to the same extent (a two-fold increase), suggesting that the proliferation of the two types of cells constituting the epidermis may be equally stimulated by FFC. These results suggest that FFC may activate skin function by promoting cell renewal via the stimulation of the proliferation and differentiation of keratinocytes and melanoblasts or melanocytes. | |||||
| 書誌情報 |
Journal of Health Science (Tokyo, Japan) 巻 53, 号 5, p. 576-584, 発行日 2007-06 |
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| 出版者 | ||||||
| 出版者 | Pharmaceutical Society of Japan | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1344-9702 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://jhs.pharm.or.jp/home.htm | |||||
| 関連名称 | http://jhs.pharm.or.jp/home.htm | |||||
