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Axonal transport of rubidium and thallium in the olfactory nerve of mice
https://repo.qst.go.jp/records/44973
https://repo.qst.go.jp/records/44973e8ad9079-71f1-4fab-9a43-2dbb17062dcc
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-09-11 | |||||
| タイトル | ||||||
| タイトル | Axonal transport of rubidium and thallium in the olfactory nerve of mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kanayama, Yousuke
× Kanayama, Yousuke× Enomoto, Shuichi× Irie, Toshiaki× Amano, Ryohei× 入江 俊章× 天野 良平 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Following intranasal administration of radioactive 86Rb+ and 201Tl+ in mice, we observed thise direct transport via the olfactory nerve pathway. The 86RbCl and 201TlCl solutions were administered to two groups of mice, the unilateral intranasal and intravenous administration group. After sacrifice, their heads were divided into the right and left side, which were then subdivided into seven parts; the nasal mucosa and brain regions were separated. Following the unilateral intranasal administration, uptake after 6 h by the olfactory bulb was significantly higher on the ipsilateral side (86Rb, 0.7 %dose; 201Tl, 0.5 %dose)than on the contralateral side (86Rb, 0.08 %dose; 201Tl, 0.15 %dose), Moreover, the 86Rb and 201Tl that accumulated in the olfactory bulb were gradually taransported to other brain regions of the olfactory tract, the telencephalon and the diencephalon on the side corresponding to the nostril used for administration. Significant differences were observed between the right and left side of the brain regions 6 and 12 h after administration. Further, 201Tl autoradiography clearly showed striped patterns of dense accumulation, localized in the region around the glomerular layer and granule cell layer of the olfactory bulb and around the olfactory cortex. These results provide clear evidence of axonal transport via the olfactory nerve pathway, from nasal cavity to the olfactory bulb, as well as to the olfactory cortex through the synaptic junctions. The olfactory transport of the 86Rb+ and 201Tl+ is thought to represent the behavior of K+ in the olfactory system. | |||||
| 書誌情報 |
Nuclear Medicine and Biology 巻 32, 号 5, p. 505-512, 発行日 2005-06 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0969-8051 | |||||
