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Progressive Changes of Pre- and Post-Synaptic Dopaminergic Biomarkers in conscious MPTP-Treated Cynomolgus Monkeys Measured by Positoron Emission Tomography
https://repo.qst.go.jp/records/44948
https://repo.qst.go.jp/records/4494874f2900c-823a-40d5-a5fd-d5d27cd83974
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-08-20 | |||||
| タイトル | ||||||
| タイトル | Progressive Changes of Pre- and Post-Synaptic Dopaminergic Biomarkers in conscious MPTP-Treated Cynomolgus Monkeys Measured by Positoron Emission Tomography | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nagai, Yuji
× Nagai, Yuji× Obayashi, Shigeru× Andou, Kiyoshi× Inaji, Motoki× Maeda, Jun× Okauchi, Takashi× Ito, Hiroshi× Suhara, Tetsuya× 永井 裕司× 大林 茂× 安東 潔× 稲次 基希× 前田 純× 岡内 隆× 伊藤 浩× 須原 哲也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Positron emission tomography (PET) is a useful technique for the consecutive gation of the relationship between changes in neurotransmission biomarkers and behavioral signs in animal models of Parkinson's disease (PD). In this study, we aimed to gate the threshold of dopamine (DA) neuron damage for the appearance of tremor by erving the longitudinal changes of pre- and post-synaptic DA biomarkers in awake monkeys g PET with multiple tracers. Three cynomolgus monkeys were treated with MPTP every 3-6 weeks until tremor was observed. Brain uptake of [11C]PE2I, [-11C]DOPA, and [11C]raclopride for DA transporter (DAT), DOPA utilization, and DA D2 receptor were ured using PET as a single set in awake condition. Sets of PET scans were repeated in el with continuous behavioral estimation. The pre-synaptic biomarkers of DA neuron in the striatum decreased [11C]PE2I binding and [-11C]DOPA uptake in an MPTP dose-ependent manner. Tremor was not observed until striatal [11C]PE2I binding was reduced to out 15% of the pretreatment level and [-11C]DOPA uptake was reduced to about 34%. DA D2 receptor measured by [11C]raclopride was not significantly changed throughout the experiment. Our results revealed that it is possible to antitatively define the threshold of the onset of behavioral PD signs by monitoring spontaneous motor activity, and in vivo PET with DAT marker can be a biomarker for early gnosis at the presymptomatic stage of PD and for high-risk groups. Synapse 61:809-819, 2007. © 2007 Wiley-Liss, Inc. | |||||
| 書誌情報 |
Synapse 巻 61, 号 10, p. 809-819, 発行日 2007-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0887-4476 | |||||
