WEKO3
アイテム
Changes of melanosome morphology associated with the differentiation of epidermal melanocytes in slaty mice
https://repo.qst.go.jp/records/44934
https://repo.qst.go.jp/records/44934e41e668e-901c-4b40-abfd-925715480445
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-08-09 | |||||
| タイトル | ||||||
| タイトル | Changes of melanosome morphology associated with the differentiation of epidermal melanocytes in slaty mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirobe, Tomohisa
× Hirobe, Tomohisa× Abe, Hiroyuki× 廣部 知久 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The slaty (Dctslt) mutation is known to reduce the activity of dopachrome tautomerase which converts dopachrome to 5,6-dihydroxyindole-2-carboxylic acid in the pathway of eumelanin synthesis and to inhibit melanosome maturation in melanocytes. However, it is not known whether the inhibition of melanosome maturation in slaty melanocytes is developmentally regulated. To address this point, changes in the morphology and maturation of melanosomes in cultured epidermal melanocytes derived from newborn mice of wild-type (black) and slaty mutant were surveyed under the electron microscopy. In black melanocytes (Dct+), almost all melanosomes were elliptical stage IV melanosomes. However, in slaty melanocytes, numerous spherical stage III melanosomes with globular depositions of pigment in addition to elliptical stage III melanosomes with intralumenal fibrils were observed. Mixed type melanosomes containing both globular deposition and intralumenal fibrils of pigment were also observed. In slaty melanocytes, spherical and mixed type melanosomes were gradually decreased after birth, whereas elliptical melanosomes were gradually increased. Stage IV melanosomes were very few in slaty melanocytes, and were not increased after birth. These results suggest that the slaty mutation blocks the melanosome maturation at stage III and affects the melanosome morphology (elliptical or spherical) in a developmental stage-specific manner. | |||||
| 書誌情報 |
The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology 巻 290, 号 8, p. 981-993, 発行日 2007-05 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1932-8486 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/ar.20547 | |||||
