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  1. 原著論文

Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor

https://repo.qst.go.jp/records/44919
https://repo.qst.go.jp/records/44919
2109ed52-84aa-4386-a5a6-7ff4514c823a
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-07-18
タイトル
タイトル Phase-dependent roles of reactive microglia and astrocytes in nervous system injury as delineated by imaging of peripheral benzodiazepine receptor
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Maeda, Jun

× Maeda, Jun

WEKO 446122

Maeda, Jun

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Higuchi, Makoto

× Higuchi, Makoto

WEKO 446123

Higuchi, Makoto

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Inaji, Motoki

× Inaji, Motoki

WEKO 446124

Inaji, Motoki

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Ji, Bin

× Ji, Bin

WEKO 446125

Ji, Bin

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Haneda, Eisuke

× Haneda, Eisuke

WEKO 446126

Haneda, Eisuke

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Okauchi, Takashi

× Okauchi, Takashi

WEKO 446127

Okauchi, Takashi

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Zhang, Ming-Rong

× Zhang, Ming-Rong

WEKO 446128

Zhang, Ming-Rong

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Suzuki, Kazutoshi

× Suzuki, Kazutoshi

WEKO 446129

Suzuki, Kazutoshi

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Suhara, Tetsuya

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WEKO 446130

Suhara, Tetsuya

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前田 純

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WEKO 446131

en 前田 純

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樋口 真人

× 樋口 真人

WEKO 446132

en 樋口 真人

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稲次 基希

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WEKO 446133

en 稲次 基希

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季 斌

× 季 斌

WEKO 446134

en 季 斌

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羽田 栄輔

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WEKO 446135

en 羽田 栄輔

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岡内 隆

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WEKO 446136

en 岡内 隆

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張 明栄

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WEKO 446137

en 張 明栄

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鈴木 和年

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WEKO 446138

en 鈴木 和年

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須原 哲也

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WEKO 446139

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抄録
内容記述タイプ Abstract
内容記述 Elevated levels of peripheral benzodiazepine receptor (PBR) in glia have been documented in diverse nervous system injuries, while the identity and spatiotemporal characteristics of the cells showing upregulation of PBR remain elusive. We examined the astrocytic and microglial expressions of PBR in rat brains during the duration of ethanol-induced neuronal insults in order to clarify the significance of PBR as a biomarker capable of detecting a distinctive subpopulation of these glial cells involved in the impairment and protection of neurons. The levels of PBR, as determined by autoradiographic analysis using a specific radioligand, [11C]DAA1106, began to significantly increase at 3 days after intrastriatal injection of ethanol, and peaked at 7 days. This was consistent with the results of double immunofluorescence staining and high-resolution emulsion autoradiography, which revealed upregulation of PBR in both microglia and astrocytes proliferating in nonoverlapping compartments of the injury site. Notably, increased expression of PBR in astrocytes was transiently observed in a manner parallel to the centripetal migration of these cells to the inflammatory lesion, which may be a response indispensable to the protection of intact tissue. Thereafter, astrocytic PBR was barely detectable, despite the presence of numerous glial fibrillary acidic protein-immunoreactive astrocytes forming glial scarring. By contrast, intense PBR signals were persistently present in microglia localized to the injury epicenter up to 90 days, notwithstanding a gradual reduction in the number of ionized calcium binding adapter molecule-1-positive amoeboid microglia between 7 and 90 days. The long-lasting PBR expression in microglia was finally supported by in vivo positron emission tomography imaging, and suggests that inflammatory tissue damage is potentially expandable unless it is tightly sealed by astrocytic scar. The present findings collectively support the utility of PBR in identifying a unique temporal pattern of astrocytic and microglial activation that conventional glial markers hardly pursue.
書誌情報 Brain Research

巻 1157, p. 100-111, 発行日 2007-07
ISSN
収録物識別子タイプ ISSN
収録物識別子 0006-8993
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