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Evaluation of primary brain tumors with FLT-PET: usefulness and limitations
https://repo.qst.go.jp/records/44902
https://repo.qst.go.jp/records/449028ab73567-c54a-4226-9e0e-b84e5c425bca
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-06-26 | |||||
| タイトル | ||||||
| タイトル | Evaluation of primary brain tumors with FLT-PET: usefulness and limitations | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Saga, Tsuneo
× Saga, Tsuneo× Kawashima, Hidekazu× Higashi, Tatsuya× et.al× 佐賀 恒夫 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose of the Report: To investigate the potential of positron emission tomography using FLT (FLT-PET) in evaluating primary brain tumors. Materials and Methods: FLT-PET was performed for 25 patients (pts) with primary brain tumors. FLT uptake in the lesion was semi-quantitatively evaluated by measuring the maximal standardized uptake value (SUVmax) and the tumor-to-normal tissue ratio (TNR). SUVmax and TNR were compared with the histological grade and the expression of the proliferation marker (Ki-67). Results: FLT uptake in normal brain parenchyma was very low, resulting in the visualization of brain tumors with high contrast. Both SUVmax and TNR significantly correlated with the malignant grade of brain gliomas, in which high SUVmax/TNR was obtained for high grade gliomas. Patients with primary lymphoma also showed SUVmax/TNR equivalent to glioblastoma. There was a positive correlation between SUVmax/TNR and the Ki-67 index. In contrast, spuriously high SUVmax and TNR were obtained in 3 of 6 pts with suspected recurrent tumors (2 pts with recurrent grade 2 glioma and one patient with post-operative granuloma), all of which showed lesion enhancement on MRI after Gd-administration. Conclusions: FLT-PET can be used to evaluate the malignant grade and proliferation activity of primary brain tumors, especially malignant brain tumors. However, the presence of benign lesions showing blood-brain barrier disruption can not be distinguished from malignant tumors and needs to be carefully evaluated. |
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| 書誌情報 |
Clinical Nuclear Medicine 巻 31, 号 12, p. 774-780, 発行日 2006-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0363-9762 | |||||
