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Results of the First Prospective Study of Carbon Ion Radiotherapy for Hepatocellular Carcinoma with Liver Cirrhosis
https://repo.qst.go.jp/records/44886
https://repo.qst.go.jp/records/44886dde1b888-4575-485e-8b7d-c95b36c0f18b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-06-18 | |||||
| タイトル | ||||||
| タイトル | Results of the First Prospective Study of Carbon Ion Radiotherapy for Hepatocellular Carcinoma with Liver Cirrhosis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Katou, Hirotoshi
× Katou, Hirotoshi× Tsujii, Hirohiko× Miyamoto, Tadaaki× Mizoe, Junetsu× Kamada, Tadashi× Tsuji, Hiroshi× Yamada, Shigeru× Kandatsu, Susumu× Yoshikawa, Kyosan× Obata, Takayuki× Ezawa, Hidefumi× Morita, Shinroku× Ootou, Masao× et.al× 加藤 博敏× 辻井 博彦× 宮本 忠昭× 溝江 純悦× 鎌田 正× 辻 比呂志× 山田 滋× 神立 進× 吉川 京燦× 小畠 隆行× 江澤 英史× 森田 新六× 大藤 正雄 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | PURPOSE: To evaluate the toxicity and antitumor effect of carbon ion radiotherapy for hepatocellular carcinoma within a Phase I-II trial. METHODS AND MATERIALS: Between June 1995 and February 1997, 24 patients with histopathologically proven hepatocellular carcinoma were treated to 15 fractions within 5 weeks in a step-wise dose-escalation study. The disease stage was Stage II in 10, IIIA in 6, and IVA in 8 patients. The Common Toxicity Criteria, Radiation Therapy Oncology Group/European Organization for the Research and Treatment of Cancer criteria, and Child-Pugh score were used to evaluate toxicity. The antitumor effect was evaluated by the tumor response, cumulative local control, and survival rates. RESULTS: During a median follow-up of 71 months (range, 63-83 months), no severe adverse effects and no treatment-related deaths occurred. The Child-Pugh score did not increase by >2 points after the start of therapy. In 78% and 75% of all patients, the score did not increase by >1 point in the early and late phase, respectively. The overall tumor response rate was 71%. The local control and overall survival rate was 92% and 92%, 81% and 50%, and 81% and 25% at 1, 3, and 5 years, respectively. CONCLUSION: Carbon ion radiotherapy appears safe and effective for patients with hepatocellular carcinoma. Additional clinical studies using a larger subject group are required to confirm the therapeutic efficacy. | |||||
| 書誌情報 |
International Journal of Radiation Oncology Biology Physics 巻 59, 号 5, p. 1468-1476, 発行日 2004 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0360-3016 | |||||
