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DNA topoisomerase inhibitor, etoposide, enhances GC-box-dependent promoter activity via Sp1 phosphorylation
https://repo.qst.go.jp/records/44877
https://repo.qst.go.jp/records/448779b142553-9b3c-4868-b8c8-5c54fe4bc3c9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-06-13 | |||||
| タイトル | ||||||
| タイトル | DNA topoisomerase inhibitor, etoposide, enhances GC-box-dependent promoter activity via Sp1 phosphorylation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Niina, Ichiro
× Niina, Ichiro× Uchiumi, Takeshi× Izumi, Hiroto× Torigoe, Takayuki× Wakasugi, Tetsuro× Igarashi, Tomonori× Miyamoto, Naoya× Onitsuka, Takamitsu× Shiota, Masaki× Okayasu, Ryuichi× Chijiiwa, Kazuo× Kohno, Kimitoshi× 岡安 隆一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Modification of transcription factors by anti-cancer agents plays an important role inboth apoptotic and survival signaling. Here we report that both DNA topoisomerase Iand II inhibitors such as SN-38 and etoposide, but not cisplatin, 5-fluorouracil or actinomycin D, can induce phosphorylation of the transcription factor Sp1. Furthermore,DNA topoisomerase inhibitors were shown to transactivate GC-box-dependent promoters such as the SV40 and VEGF promoters. The phosphorylated form of Sp1 was detectable within 30 minutes of inhibitor treatment and was greatly diminished by the presence of the PI3K inhibitor wortmannin and by DNA-dependent protein kinase (DNA-PK) knockdown. We also confirmed that the phosphorylated form of DNA-PK was increased by treatment with both etoposide and SN-38. Taken together, these findings demonstrate a novel genomic response to anticancer agents that induce Sp1 phosphorylation, and might contribute to tumor progression and drug resistance. |
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| 書誌情報 |
Cancer Science 巻 98, 号 6, p. 858-863, 発行日 2007-04 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1347-9032 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/j.1349-7006.2007.00476.x | |||||
