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Mapping of human cerebral sigma1 receptors using positron emission tomography and [11C]SA4503
https://repo.qst.go.jp/records/44848
https://repo.qst.go.jp/records/448482fddf1a9-d39c-4b0e-b463-755d9121ad05
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-05-22 | |||||
| タイトル | ||||||
| タイトル | Mapping of human cerebral sigma1 receptors using positron emission tomography and [11C]SA4503 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sakata, Muneyuki
× Sakata, Muneyuki× Kimura, Yuichi× Naganawa, Mika× Oda, Keiichi× Ishii, Kenji× Chihara, Kunihiro× Ishiwata, Kiichi× 木村 裕一× 長縄 美香× 織田 圭一× 石井 賢二× 石渡 喜一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The objective of this study was to establish the kinetic analysis for mapping sigma1 receptors (delta 1Rs) in the human brain by positron emission tomography (PET) with [11C]SA4503. The delta 1Rs are considered to be involved in various neurological and psychiatric diseases. [11C]SA4503 is a recently developed radioligand with high and selective affinity for delta 1Rs, and we have first applied it to clinical studies. Nine healthy male subjects each underwent a dynamic 90-min PET scan after injection of [11C]SA4503. In addition to the baseline measurement, three of the nine subjects underwent a second [11C]SA4503-PET after partial blockade of delta 1Rs by oral administration of haloperidol, a sigma receptor antagonist. Full kinetic analysis using two times nonlinear estimations was applied for fitting a two-tissue three-compartment model to determine the binding potential (BP) and total distribution volume (tDV) of [11C]SA4503. Graphical analysis with a Logan plot was also applied for estimations of tDV. The regional distribution patterns of BP and tDV in 11 regions were compatible with those of previously reported delta 1Rs in vitro. The reduced binding sites of delta 1Rs by haloperidol were appropriately evaluated. The tDVs derived from the two methods matched each other well. The Logan plot offered images of the tDV, which reflected delta 1R densities, and the tDV in the images decreased after haloperidol loading. Moreover, comparison of BPs calculated with and without metabolite correction for plasma input function indicated that the metabolite correction could be omitted. We concluded that this method enables the quantitative analysis of delta 1Rs in the human brain. | |||||
| 書誌情報 |
NeuroImage 巻 35, 号 1, p. 1-8, 発行日 2007-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1053-8119 | |||||
