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  1. 原著論文

Combined genotoxic effects of radiation and a tobacco-specific nitrosamine in the lung of gpt delta transgenic mice

https://repo.qst.go.jp/records/44821
https://repo.qst.go.jp/records/44821
4d2387fa-442b-4754-b7ba-76eb27377f42
Item type 学術雑誌論文 / Journal Article(1)
公開日 2007-04-04
タイトル
タイトル Combined genotoxic effects of radiation and a tobacco-specific nitrosamine in the lung of gpt delta transgenic mice
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Ikeda, Megumi

× Ikeda, Megumi

WEKO 445107

Ikeda, Megumi

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Masumura, Kenichi

× Masumura, Kenichi

WEKO 445108

Masumura, Kenichi

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Sakamoto, Yasuteru

× Sakamoto, Yasuteru

WEKO 445109

Sakamoto, Yasuteru

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Bing, Wang

× Bing, Wang

WEKO 445110

Bing, Wang

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Nenoi, Mitsuru

× Nenoi, Mitsuru

WEKO 445111

Nenoi, Mitsuru

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Hayata, Isamu

× Hayata, Isamu

WEKO 445112

Hayata, Isamu

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Nohmi, Takehiko

× Nohmi, Takehiko

WEKO 445113

Nohmi, Takehiko

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et.al

× et.al

WEKO 445114

et.al

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池田 恵

× 池田 恵

WEKO 445115

en 池田 恵

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増村 健一

× 増村 健一

WEKO 445116

en 増村 健一

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坂元 康晃

× 坂元 康晃

WEKO 445117

en 坂元 康晃

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王 冰

× 王 冰

WEKO 445118

en 王 冰

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根井 充

× 根井 充

WEKO 445119

en 根井 充

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早田 勇

× 早田 勇

WEKO 445120

en 早田 勇

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能美 健彦

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WEKO 445121

en 能美 健彦

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抄録
内容記述タイプ Abstract
内容記述 It is important to evaluate the health effects of low-dose-rate or low-dose radiation in combination with chemicals as humans are exposed to a variety of chemical agents. Here, we examined combined genotoxic effects of low-dose-rate radiation and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), the most carcinogenic tobacco-specific nitrosamine, in the lung of gpt delta transgenic mice. In this mouse model, base substitutions and deletions can be separately analyzed by gpt and Spi - selections, respectively. Female gpt delta mice were either treated with gamma-irradiation alone at a dose rate of 0.5, 1.0 or 1.5 mGy/h for 22 h/day for 31 days or combined with NNK treatments at a dose of 2 mg/mouse/day, i.p. for four consecutive days in the middle course of irradiation. In the gpt selection, the NNK treatments enhanced the mutation frequencies (MFs) significantly, but no obvious combined effects of gamma-irradiation were observable at any given radiation dose. In contrast, NNK treatments appeared to suppress the Spi - large deletions. In the Spi- selection, the MFs of deletions more than 1 kb in size increased in a dose-dependent manner. When NNK treatments were combined, the dose-response curve became bell-shaped where the MF at the highest radiation dose decreased substantially. These results suggest that NNK treatments may elicit an adaptive response that eliminates cells bearing radiation-induced double-strand breaks in DNA. Possible mechanisms underlying the combined genotoxicity of radiation and NNK are discussed, and the importance of evaluation of combined genotoxicity of more than one agent is emphasized.
書誌情報 Genetic Toxicology and Environmental Mutagenesis : A Section of Mutation Research

巻 626, 号 1/2, p. 15-25, 発行日 2007-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 1383-5718
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