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Excess tyrosine stimulates eumelanin and pheomelanin synthesis in cultured slaty melanocytes from neonatal mouse epidermis
https://repo.qst.go.jp/records/44818
https://repo.qst.go.jp/records/44818ae4b5b4d-3155-4e94-9264-e585610ba4cb
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-04-03 | |||||
| タイトル | ||||||
| タイトル | Excess tyrosine stimulates eumelanin and pheomelanin synthesis in cultured slaty melanocytes from neonatal mouse epidermis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirobe, Tomohisa
× Hirobe, Tomohisa× Wakamatsu, Kazumasa× Ito, Shosuke× 廣部 知久 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Mouse slaty (Dctslt) mutation is known to reduce the activity of dopachrome tautomerase (DCT). The reduced DCT activity inhibits melanosome maturation and reduces the melanin content in the skin, hairs and eyes. It is not known whether eumelanin and pheomelanin synthesis in slaty melanocytes is modulated by melanogenic factors. In this study, to address this point epidermal melanocytes derived from 0.5-, 3.5- and 7.5-day-old wild-type mice (Dct+/Dct+) at the slaty locus and from congenic mice mutant (Dctslt/Dctslt) at that locus were cultured in serum-free primary culture with or without additional L-tyrosine (Tyr). The content of melanin was measured by high performance liquid chromatography in the cultured melanocytes as well as culture supernatants in serum-free primary culture. L-Tyr was found to increase the content of pheomelanin in addition to eumelanin in cultured slaty melanocytes and cuture supernatants at all ages tested. The eumelanin and pheomelanin contents in culture supernatants were greater than in cultured melanocytes. The eumelanin and pheomelanin contents in culture supernatants from 7.5-day-old slaty melanocytes in the presence of L-Tyr were greater than those from wild-type melanocytes. These results suggest that the inhibition of the eumelanin synthesis by the slaty mutation can be partly restored by the addition of excess L-Tyr. The eumelanin and pheomelanin in slaty melanocytes may be difficult to be accumulated in them and easily released from them during skin development. L-Tyr may stimulate this release. | |||||
| 書誌情報 |
Zoological Science 巻 24, 号 3, p. 209-217, 発行日 2007-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0289-0003 | |||||
