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Preparation and biodistribution of novel 99mTc(CO)3-CNR complexes for myocardial imaging
https://repo.qst.go.jp/records/44794
https://repo.qst.go.jp/records/44794971c8d84-bbfd-4cf8-9fc1-7c850893adfc
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-02-19 | |||||
| タイトル | ||||||
| タイトル | Preparation and biodistribution of novel 99mTc(CO)3-CNR complexes for myocardial imaging | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hao, Guiyang
× Hao, Guiyang× JIANYING, ZANG× BOLI, LIU× Ｈａｏ Ｇｕｉｙａｎｇ |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We evaluated lipophilicity and biodistribution of a series of 99mTc(CO)3-ether isonitrile complexes to determine whether different lipophilicity and structure of isonitrile ligands would improve the imaging properties of the radiopharmaceutical for the heart. Novel 99mTc(CO)3-MIBI analogs were prepared and analyzed by radio-HPLC, and their lipophilicity was determined. These new complexes could be bi- or tri-substituted in specified pH conditions like 99mTc(CO)3-MIBI. These new complexes exhibited low liver, lungs and blood uptake compared with [99mTc(CO)3(MIBI)3]+ though their heart uptake was not so high. Among these complexes, [99mTc(CO)3(EPI)2(OH2)]+ showed higher target to non-target ratios at 5 and 30 min post-injection than that of [99mTc(CO)3(MIBI)3]+. Copyright # 2007 John Wiley & Sons, Ltd |
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| 書誌情報 |
Journal of Labelled Compounds & Radiopharmaceuticals 巻 50, 号 1, p. 13-18, 発行日 2007-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0362-4803 | |||||
