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Radiation-induced response of micro RNA expression in murine embryonic stem cells.
https://repo.qst.go.jp/records/44771
https://repo.qst.go.jp/records/4477106d9fe3a-0f7f-4ed9-b937-c69edbdc4f26
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-01-17 | |||||
| タイトル | ||||||
| タイトル | Radiation-induced response of micro RNA expression in murine embryonic stem cells. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ishii, Hideshi
× Ishii, Hideshi× Saito, Toshiyuki× 齋藤 俊行 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Despite the importance of embryonic stem cells in embryology and regenerative medicine, their response to DNA damage is not fully understood. Here we studied the expression profiles of small RNAs approximately 22 nucleotides long called micro RNAs, which play an important role in developmental regulation in plants and animals. We identified a group of micro RNAs with increased expression after exposure to radiation (compared with murine fibroblasts) and characterized putative target genes. These micro RNA sequences are conserved in mice, chickens and humans with similar genomic organizations, suggesting that a common regulatory network is involved in stem cell regulation in response to DNA damage. Micro RNAs might be useful as therapeutic tools to control DNA damage response in pluripotent stem cells. | |||||
| 書誌情報 |
Medicinal Chemistry 巻 2, 号 6, p. 555-563, 発行日 2006-11 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1573-4064 | |||||
