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The eumelanin and pheomelanin contents in dorsal hairs of female recessive yellow mice are greater than in male.
https://repo.qst.go.jp/records/44762
https://repo.qst.go.jp/records/44762ffda176b-d354-4231-900e-2b0ed03de462
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2007-01-10 | |||||
| タイトル | ||||||
| タイトル | The eumelanin and pheomelanin contents in dorsal hairs of female recessive yellow mice are greater than in male. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirobe, Tomohisa
× Hirobe, Tomohisa× Wakamatsu, Kazumasa× Ito, Shosuke× 廣部 知久 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | (1) Background The murine recessive yellow (Mc1re) is a loss-of-function mutation in the receptor for a-melanocyte-stimulating hormone (MSH), melanocortin receptor 1 (MC1R), and produces yellow coats by inducing pheomelanin synthesis in hair follicular melanocytes. (2) Objective It is not known whether the Mc1re mutation affects pheomelanin synthesis in other skin sites. In this study, the eumelanin and pheomelanin contents in the epidermis and dermis as well as hairs of wild-type and mutant mice were measured. (3) Materials and methods The content of melanin was measured by high performance liquid chromatography. (4) Results The eumelanin contents in the epidermis and dermis of newborn wild-type (Mc1r+/Mc1r+) mice (0.5, 3.5, 5.5, and 7.5 days) were much greater than those of mutant (Mc1re/Mc1re) mice, whereas the pheomelanin contents in the epidermis and dermis of mutant mice were much greater than those of wild-type mice. No sex differences in the contents of eumelanin and pheomalanin in the epidermis and dermis both in mutant and wild-type mice were observed. The eumelanin contents in mutant hairs (5-week-old) was much smaller than in wild-type hairs, whereas the pheomelanin contents in mutant hairs was much greater than in wild-type hairs. However, the eumelanin and pheomelanin contents in mutant female hairs were greater than in male. These sex differences were not observed in wild-type mice. (5) Conclusion The Mc1re gene stimulates pheomelanin synthesis in the epidermis, dermis and hair follicles. In addition, eumelanin and pheomelanin contents in Mc1re/Mc1re hairs may be influenced by the sex difference. |
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| 書誌情報 |
Journal of Dermatological Science 巻 45, 号 1, p. 55-62, 発行日 2007-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0923-1811 | |||||
