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Biological dose calculation with Monte Carlo physics simulation for heavy-ion radiotherapy
https://repo.qst.go.jp/records/44747
https://repo.qst.go.jp/records/447471c8bd4a2-a811-4c3d-b1c3-146fb8c9ad20
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-12-21 | |||||
| タイトル | ||||||
| タイトル | Biological dose calculation with Monte Carlo physics simulation for heavy-ion radiotherapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kase, Yuuki
× Kase, Yuuki× Kanematsu, Nobuyuki× Kanai, Tatsuaki× Matsufuji, Naruhiro× 加瀬 優紀× 兼松 伸幸× 金井 達明× 松藤 成弘 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Treatment planning of heavy-ion radiotherapy involves predictive calculation of not only physical dose but also biological dose in a patient body. The biological dose is defined as the product of the physical dose and the relative biological effectiveness (RBE). In carbon-ion radiotherapy at National Institute of Radiological Sciences, the RBE value has been defined as the ratio of the 10% survival dose of 200 kVp X-ray to that of the radiation of interest for in vitro human salivary gland tumor cells. In this article, the physical and biological dose distributions of a typical therapeutic carbon-ion beam are calculated using a GEANT4 Monte Carlo simulation toolkit in comparison with those with the biological dose estimate system based on the one-dimensional beam model currently used in treatment planning. The results differed between the GEANT4 simulation and the one-dimensional beam model, indicating the physical limitations in the beam model. This study demonstrates that the Monte Carlo physics simulation technique can be applied to improve the accuracy of the biological dose distribution in treatment planning of heavy-ion radiotherapy. | |||||
| 書誌情報 |
Physics in Medicine and Biology 巻 51, 号 24, p. N467-N475, 発行日 2006-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0031-9155 | |||||
