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Clinical diagostic indicators of renal and bone damage in rats intramuscularly injected with depleted uranium
https://repo.qst.go.jp/records/44727
https://repo.qst.go.jp/records/44727caf65c15-69c3-4f98-9ada-6f9bc73dfd0f
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-11-30 | |||||
| タイトル | ||||||
| タイトル | Clinical diagostic indicators of renal and bone damage in rats intramuscularly injected with depleted uranium | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Fukuda, Satoshi
× Fukuda, Satoshi× Ikeda, Mizuyo× Chiba, Momoko× Kaneko, Kazunari× 福田 俊× 池田 瑞代 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The toxic effects and changes in biochemical markers related to kidney and bone in depleted uranium (DU) injected rats were examined in order to clarify the relation between the clinical biochemical markers and the degree of damage in these organs. Male Wistar rats were received a single injection in the femoral muscles with 0.2, 1.0 or 2.0 mg/kg of DU which was dissolved in nitric acid solution adjusted to pH3.2, for comparison with the nitric acid solution injected and control groups. Urine and feces were collected periodically over a 24 hr. period. Thereafter, the rats were killed at 28 days after DU injection. The body weights of the DU-injected groups decreased dose-dependently for the first 3-7 days, and then began to increase. The DU concentrations in the urine and feces decreased rapidly within 3-7 days after DU injection. Urinary N-acetyl-b-_-glucosaminidase (NAG)/creatinine peaked at the third day after DU injection, with a high correlation to the injected DU doses. There were high correlations among the injected DU doses, DU concentrations in the kidney, and urinary NAG/creatinine values that were obtained at 28 days, respectively. The blood urea nitrogen (BUN) and creatinine in the serum also showed a high correlation with the DU-injected doses. The results indicated that urinary NAG/creatinine, BUN and creatinine in serum were useful indicators to diagnose the renal damage by DU as well as to estimate the DU intake and concentration in the kidney when the intake is over 2mg/kg DU. The total bone mineral density of the proximal metaphysis of the tibia decreased in the 2 mg/kg DU group. In addition, alterations of the bone trabecular structure by inhibiting bone formation and promoting bone resorption were observed by bone histomorphomtery. The bone biochemical markers osteocalcin, tartrate-resistance acid phosphatase (TRAP), pyridinoline, and rat-parathyroid hormone (PTH) increased in all the DU injected groups, indicating that these markers were useful as sensitive indicators for diagnosing bone damage, even if the DU-injected dose is low. | |||||
| 書誌情報 |
Radiation Protection Dosimetry 巻 118, 号 3, p. 307-314, 発行日 2006-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0144-8420 | |||||
