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Preliminary evaluation of toxicologic and carcinogenic risks of copper gluconate in rats given multiple carcinogens
https://repo.qst.go.jp/records/44685
https://repo.qst.go.jp/records/44685468cc906-25cd-4191-9c5f-0637ed356512
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-10-24 | |||||
| タイトル | ||||||
| タイトル | Preliminary evaluation of toxicologic and carcinogenic risks of copper gluconate in rats given multiple carcinogens | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yoshida, Midori
× Yoshida, Midori× 吉田 緑 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The present study was conducted as a preliminary evaluation of toxicologic and carcinogenic risks of copper gluconate and to determine its optimal dose for use in an upcoming study utilizing the medium-term multi-organ carcinogenisis protocol. Male BrlHan:WIST@Jcl (GALAS) rats were initially treated with N-nitrosodiethylamine, N-methylnitrosourea, 1,2-dimethylhydrazine, N-butyl-N-(4-hydroxybutyl)-nitrosoamine and 2,2'-dihydorxy-di-n-propylmitrosamine for a total multiple initiation period for 4 weeks. In addition, rats were fed a diet containing copper gluconate at 0, 1000, 3000, 4800, 6000, or 12000 ppm from the commencement for 13 weeks. While no systemic toxicity was detected, hepatic granulomas were observed at copper gluconate dose of 6000 ppm, or greater. Hepatic copper accumulation and metallothionein induction were demonstreated at doses of 3000 ppm and 1000 ppm, respectively, or greater. Putative preneoplastic lesions in the liver appeared to increase at a dose of 12000 ppm, and 8-hydorxydeoxyguanosine formation was enhanced at dose of 6000 ppm, or greater. These results suggest that copper gluconate exerts effects on the liver at the relatively low dietary dose of 1000 ppm and causes hepatic infury at 6000 ppm. The hepatotoxicity and possible hepatocarcinogenicity of copper gluconate may be attributable to oxidative stress due to the impairment of hepatic copper metabolism. | |||||
| 書誌情報 |
Journal of Toxicologic Pathology 巻 19, 号 3, p. 129-135, 発行日 2006-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0914-9198 | |||||
