WEKO3
アイテム
Proposal of blood volume-corrected model for quantification of regional cerebral blood flow with H2 15O-PET and its application to AVF.
https://repo.qst.go.jp/records/44675
https://repo.qst.go.jp/records/44675cea1bd18-c62f-40d1-abd2-bcdce9299388
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-10-18 | |||||
| タイトル | ||||||
| タイトル | Proposal of blood volume-corrected model for quantification of regional cerebral blood flow with H2 15O-PET and its application to AVF. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Seki, Chie
× Seki, Chie× et.al× 関 千江 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose. It is generally assumed that vascular tracer activity is negligible in the quantification of regional cerebral blood flow (gammaCBF) with H215O and positron emission tomography (PET) under normal conditions. We attempted to surpass the assumption of abnormal vascular conditions where the vascular tracer activity is significant by introducing the vascular component into the model. Materials and methods. H215O-dynamic and C15O PET scans were performed in an arterivenous fistula (AVF) patient. Time-activity curves of regions of interest (ROIs) were analyzed with nonlinear least -square approximation to estimate the gammaCBF and fractional arterial blood volume (va) simultaneously with the proposed model and the standard model. Results. The proposed model curve showed a fit to the time-activity curve of H215O at an ROI containing an enlarged vascular space induced by the AVF. The relation between the estimated va and CBV obtained with C15O-PET revealed that the ratio of va to CBV was approximately 0.23. The estimated gammaCBF with the proposed model in nonlesion ROIs corresponded to those of the standard model, with the estimated Vd 0.94ml/ml. Conclusion. The results supported the hypothesis that the blood volume-corrected model is applicable to the quantification of gammaCBF in a region with abnormal vascular structure. Furthermore,one of the advantages of the gammaCBF and arterial blood volume with dynamic-H215O PET scans. |
|||||
| 書誌情報 |
Radiation Medicine 巻 24, 号 4, p. 260-268, 発行日 2006 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0288-2043 | |||||
