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Carbon beam therapy overcomes the radiation resistance of uterine cervical cancer originating from hypoxia
https://repo.qst.go.jp/records/44609
https://repo.qst.go.jp/records/44609795b35e4-458d-43fa-8a32-fe6a33fd5dde
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-09-19 | |||||
| タイトル | ||||||
| タイトル | Carbon beam therapy overcomes the radiation resistance of uterine cervical cancer originating from hypoxia | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nakano, Takashi
× Nakano, Takashi× Suzuki, Yoshiyuki× Ohno, Tatsuya× Kato, Shingo× Suzuki, Michiya× Morita, Shinroku× Satou, Shinichirou× Oka, Kuniyuki× Tsujii, Hirohiko× 中野 隆史× 鈴木 義行× 大野 達也× 加藤 眞吾× 鈴木 通也× 森田 新六× 佐藤 眞一郎× 岡 邦行× 辻井 博彦 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: High linear energy transfer (LET) particles are believed to decrease tumor radiation resistance originating from hypoxia. However, no proof of this effect has been provided by clinical trials and related clinical research. Hence, we investigated the radiation biological aspects of high LET carbon beam therapy on cervical cancer. Experimental Design: This study involved 49 patients with stage 3B bulky and 4A cervical cancer treated with high LET carbon beams between October 1995 and June 2000. Oxygen partial pressure (pO2) was measured by using a needle-type polarographic oxygen electrode. Results: The 4-year disease-free survival rates of patients with pO2=<20 mmHg (hypoxic tumor) and >20 mmHg (oxygenated tumor) before treatment were 37% and 21%, respectively. The local control rates of hypoxic and oxygenated tumors before treatment were 58% and 54%, respectively. The disease-free survival rates of hypoxic and oxygenated tumors assessed by oxygen status at the 5th day of irradiation (5th Day) were 33% and 32%, respectively. The local control rates of hypoxic and oxygenated tumors at the 5th Day were 60% and 58%, respectively. There was no significant prognostic difference between the hypoxic and oxygenated tumors. Conclusion: The similar disease-free survival and local control rates between the hypoxic and oxygenated tumors before and during treatment indicated that the role of the tumor oxygenation status was not so important in local control in carbon beam therapy. These results indicated that high LET carbon beam irradiation might reduce the radiation-resistant nature stemming from tumor hypoxia. |
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| 書誌情報 |
Clinical Cancer Research 巻 12, 号 7, p. 2185-2190, 発行日 2006-04 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1078-0432 | |||||
