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Analysis of Non-genetic Risk Factors for Adverse Skin Reactions to Radiotherapy among 284 Breast Cancer Patients
https://repo.qst.go.jp/records/44608
https://repo.qst.go.jp/records/4460829593f9b-e0c4-4531-8ed7-756e24e634c4
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-09-15 | |||||
| タイトル | ||||||
| タイトル | Analysis of Non-genetic Risk Factors for Adverse Skin Reactions to Radiotherapy among 284 Breast Cancer Patients | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Iwakawa, Mayumi
× Iwakawa, Mayumi× Noda, Shuhei× Yamada, Shigeru× Yamamoto, Naohito× Miyazawa, Yukimasa× Yamazaki, Hideya× Kawakami, Yoshihiro× Matsui, Yoshifumi× Tsujii, Hirohiko× Mizoe, Junetsu× Oda, Eisei× Yukihiro, Fukunaga× Imai, Takashi× 岩川 眞由美× 野田 秀平× 山田 滋× 山本 尚人× 宮澤 幸正× 山崎 秀哉× 川上 義弘× 松井 芳文× 辻井 博彦× 溝江 純悦× 小田 英世× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We analyzed non-genetic risk factors for adverse skin reactions to irradiation at 4 collaborating Japanese institutions, to design future investigation into genetic risk factors for adverse skin reactions to irradiation in a multicenter setting.Methods: From April 2001, 284 breast cancer patients, who underwent radiotherapy with breast-conserving surgery, were enrolled from 4 collaborating institutions in Japan. We graded skin reactions according to international scoring systems. Clinical factors were tested against adverse effects.Results: Grade 1+ skin reactions were observed in 261 (92%) of the patients in less than 3 months, 118 (42%) at 3 months, and 29 (10%) at 6 months in the late phase. Univariate analysis of treatment risk factors (such as the use of a multi-leaf colimeter, wedge-filter, or immobilization device) for skin reactions revealed a significant association (p< 0.0001). After a variable selection procedure with logistic regression, the institution, operative procedure, and magnitude of photon energy remained significantly associated with acute skin reactions. Only the institution was an explanatory variable for skin reactions at 3 and 6 months in the final logistic model.Conclusion: After stratification, substantial remaining variations in the occurrence of skin reactions of a given level suggested that individual genetic factors contribute markedly to individual radiosensitivity. Analysis of genetic factors associated with adverse effects would be possible by stratifying patients according to institution. Selection of eligible institutions, where appropriate treatment modalities could be performed, would also be possible when planning such a study. | |||||
| 書誌情報 |
Breast Cancer 巻 13, 号 3, p. 300-307, 発行日 2006-07 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1340-6868 | |||||
