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Disruption of spermatogenic cell adhesion and male infertility in mice lacking TSLC1/IGSF4, an immunogloblin superfamily cell adhesion molecule
https://repo.qst.go.jp/records/44602
https://repo.qst.go.jp/records/4460279c8c748-6469-465d-b759-569d86ec7953
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-09-11 | |||||
| タイトル | ||||||
| タイトル | Disruption of spermatogenic cell adhesion and male infertility in mice lacking TSLC1/IGSF4, an immunogloblin superfamily cell adhesion molecule | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yoshida, Midori
× Yoshida, Midori× et.al× 吉田 緑 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | TSLC1/IGSF4, an immunoglobulin superfamily moelcule, is predominantly expressed in the brain, lungs, and testes and plays important roles in epithelial cell adhesion, cancer invasion, and synapse formation. We generated Tslc1/Igsf4-deficient mice by disrupting exon 1 of the gene and found that Tslc1-/- mice were born with the expected Mendelian ratio but that Tslc1-/- male mice infertile. In 11-week-old adult Tslc1-/- mice, the weight of a testis was 88% that in Tslc +/+ mice, and the number of sperm in the semen was approximately 0.01% that in Tslc1+/+ mice. Histological analysis revealed that hte round spermatids and the pachytene spermatocytes failed to attach to the Sertoli cells in the semiferous tubules and sloughed off into the lumen with apoptosis in the Tslc -/- mice. On the other hand, the spermatogonia and the instersitial cells, including Leydig cells, were essentially unaffected. In the Tslc1+/+ mice, TSLC1/IGSF4 expression was observed in the spermatogenic cells from the intermediate spermatogonia to the early pachytene spermatocytes and from spermatids at step 7 or later. These findings suggest taht TSLC1/IGSF4 expression in indispensable for the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa. | |||||
| 書誌情報 |
Molecular and Cellular Biology 巻 26, 号 9, p. 3610-3624, 発行日 2006-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0270-7306 | |||||
