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Adenosine-Induced Coronary Flow Researve in Watanabe Heritable Hyperlipidemic Rabbits
https://repo.qst.go.jp/records/44425
https://repo.qst.go.jp/records/44425dc3e95fe-067d-4198-a350-121f1a278713
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-07-06 | |||||
| タイトル | ||||||
| タイトル | Adenosine-Induced Coronary Flow Researve in Watanabe Heritable Hyperlipidemic Rabbits | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yoshida, Katsuya
× Yoshida, Katsuya× Tadokoro, Hiroyuki× Suzuki, Kazutoshi× Tanada, Shuji× Masuda, Yoshiaki× et.al× 吉田 勝哉× 田所 裕之× 鈴木 和年× 棚田 修二 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The Watanabe heritable hyperlipidemic (WHHL) rabbit develops coronary atherosclerosis and hypercholesterolemia because of a genetic deficiency of low-density lipoprotein receptors and is therefore a good animal model for studying the relationships of coronary atherosclerosis, hypercholesterolemia and coronary flow reserve. The aima of the present study was to assess myocardial perfusion at baseline and during adenosine infusion (0.2mg/kg-1.min-1) in 8 WHHL rabbits (13.8 0.5 months) with 13N-ammonia, small-animal positron emission tomography (PET) and colored microspheres. Results were compared with those from 6 age-matched Japanese white rabbits. Plaque distribution was also examined in the extraural coronary arteries. All 8 WHHL rabbits had coronary plaques, with 6 showing multiple plaques. Mean global myocardial blood flow (ml/min-1/g-1) did not differ significantly between control and WHHL groups both at baseline (3.67 0.72 vs 4.26 1.12ml/min-1/g-1, p=NS) and with adenosine (7.92 2.00 vs 9.27 2.91 ml/min-1/g-1,p=NS), nor did coronary flow reserve (2.16 0.37 vs 2.18 0.41, p=NS). None showed evidence of regional perfusion abnormalities by visual and semiquantiative analyses of PET images. It was concluded that WHHL rabbits preserve adenosine-induced coronary flow reserve despite coronary atherosclerosis and hypercholesterolemia, suggesting that a compensatory mechanism develops in this animal model. | |||||
| 書誌情報 |
Japanese Circulation Journal 巻 64, 号 12, p. 971-976, 発行日 2000-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0047-1828 | |||||
