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Positron Emission Tomographic Measurement of Acetylcholinesterase Activity Reveals Differential Loss of Ascending Cholinergic Systems in Parkinson's Disease and Progressive Supranuclear Palsy
https://repo.qst.go.jp/records/44412
https://repo.qst.go.jp/records/44412c84c7c6b-c806-4bb1-b430-2aa425ff95e9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-07-06 | |||||
| タイトル | ||||||
| タイトル | Positron Emission Tomographic Measurement of Acetylcholinesterase Activity Reveals Differential Loss of Ascending Cholinergic Systems in Parkinson's Disease and Progressive Supranuclear Palsy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shinoto, Hitoshi
× Shinoto, Hitoshi× Namba, Hiroki× Yamaguchi, Mika× Fukushi, Kiyoshi× Nagatsuka, Shinnichiro× Iyo, Masaomi× Asahina, Masato× Hattori, Takamichi× Tanada, Shuji× Irie, Toshiaki× 篠遠 仁× 難波 宏樹× 福士 清× 長塚 伸一郎× 棚田 修二× 入江 俊章 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We measured brain acetylcholinesterase activity in 16 patients with Parkinson's disease (PD), 12 patients with progressive supranuclear palsy(PSP), and 13 age-matched controls, using N-methyl-4-[11C]piperidyl acetate and positron emission tomography. Kinetic analysis was performed to calculate k3, an index of acetylcholinesterase activity. In PD patients, there was a significant reduction (-17%) of cerebral cortical k3 compared with normal controls, whereas there was only a nonsignificant reduction (-10%) of cortical k3 in PSP patients. However, there was a prominent reduction (-38%) of thalamic k3 in PSP patients compared with normal controls, whereas there was only a nonsignificant reduction (-13%) of thalamic k3 in PD patients. The results suggest that there is a loss of cholinergic innervation to the cerebral cortex in association with cholinergic innervation to the thalamus in PD, whereas there is a preferential loss of cholinergic innervation to the thalamus in PSP. When the thalamic to cerebral cortical k3 ratio was taken for each subject, PD and PSP were separated, suggesting that positron emission tomography measurement of acetylcholinesterase activity may be useful for differentiating the two similar disorders. | |||||
| 書誌情報 |
Annals of Neurology 巻 46, 号 1, p. 62-69, 発行日 1999-07 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0364-5134 | |||||
