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Preparation of 18F-labeled 6- and 2-fluoro-9-benzylpurine as a Potential Brain-scanning Agent
https://repo.qst.go.jp/records/44390
https://repo.qst.go.jp/records/44390dacfd5c7-2667-4b28-abb8-95a6cedcea8c
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-07-03 | |||||
| タイトル | ||||||
| タイトル | Preparation of 18F-labeled 6- and 2-fluoro-9-benzylpurine as a Potential Brain-scanning Agent | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Irie, Toshiaki
× Irie, Toshiaki× Fukushi, Kiyoshi× Inoue, Osamu× Ido, Tatsuo× et.al× 入江 俊章× 福士 清× 井上 修 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The preparations of [18F]-6-fluoro-9-benzylpurine(I) and [18F]-2-fluoro-9-benzylpurine(II) are described. (I) was prepared by two methods: (i) halogen exchange of 6-chloro-9-benzylpurine with Ag 18F; and (ii) displacement of trimethylpurin-6-ylammonium chloride with K 18F, followed by 9N benzylation. The latter labeling method was far superior to the former, both in radiochemical yield and in specific activity. (I) was relatively stable in a Tris-HCl buffer (0.4M, pH 7.6) at 37 degree-C, but was easily hydrolyzed in 1 N HCl. Biodistribution of (I) in mice demonstrated high uptake in the brain. (I) can be expected to be a potential brain-scanning radiopharmaceutical for positron computed tomography. | |||||
| 書誌情報 |
International Journal of Applied Radiation and Isotopes 巻 33, p. 633-636, 発行日 1982 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0020-708X | |||||
