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A comparative study of 11C-choline PET and [18F]fluorodeoxyglucose PET in the evaluation of lung cancer
https://repo.qst.go.jp/records/44280
https://repo.qst.go.jp/records/44280d53a094a-4f6e-4956-bb4c-8325e0556d20
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-06-20 | |||||
| タイトル | ||||||
| タイトル | A comparative study of 11C-choline PET and [18F]fluorodeoxyglucose PET in the evaluation of lung cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Khan, N
× Khan, N× Oriuchi, Noboru× Zhang, Hong× Higuchi, Tetsuya× Mei, Tian× Inoue, Tomio× Satou, Noriko× Endou, Keigo× 張 宏× 井上 登美夫× 遠藤 啓吾 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The purpose of this study was to compare the diagnostic value of 11C-choline positron emission tomography (PET) and [18F]fluorodeoxyglucose (FDG) PET imaging in the detection of primary lung cancer and mediastinal lymph node metastases. Seventeen patients with histologically proven primary lung cancer were examined with both 11C-choline and FDG PET within a week of each study. Lung cancers were analysed visually and semiquantitatively using the ratio of tumour-to-normal radioactivity (T/N ratio) and standardized uptake value (SUV). Mediastinal lymph node metastases were analysed visually. Although both techniques delineated focal lesions with an increase intracer accumulation in 13 patients, FDG PET identified three additional patients in whom 11C-choline PET did not visualize any lesion. In the detection of lung cancer <2 cm in size, FDG PET provided higher sensitivity (six of seven, 85.7%) than 11C-choline PET (four of seven, 57.1%). THe T/N ratio and SUV were significantly higher with FDG PET (T/N ratio, 7.43 6.22, SUV, 4.05 3.05) than these were with 11C-choline PET (T/N ratio, 2.93 1.19, SUV, 2.93 0.79)(p<0.001). Tｈere was a significant positive correlation between tha T/N ratios and SUVs of FDG and 11C-choline. In the assessment of mediastinal lymph node involvement, FDG PET detected lymph node metastases in two patients who were negative on 11C-choline PET, whereas both techniques could not detect tumour involvement in one patient, Both techniques have clinical value for the non-invasive detection of primary lung cancer that is 2 cm or greater in size. However, FDG PET is superior to 11C-choline PET in the detection of lung cancer that is less than 2 cm in diameter and in mediastinal lymph node metastases. | |||||
| 書誌情報 |
Nuclear Medicine Communications 巻 24, p. 359-366, 発行日 2003 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0143-3636 | |||||
