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Postnatal Changes in Mice Exposed In Utero to Fast Neutrons
https://repo.qst.go.jp/records/44253
https://repo.qst.go.jp/records/44253bcc5e43d-905a-46bf-b6e2-48e093377f22
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-06-13 | |||||
| タイトル | ||||||
| タイトル | Postnatal Changes in Mice Exposed In Utero to Fast Neutrons | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ohmachi, Yasushi
× Ohmachi, Yasushi× Ishida, Yuka× Hiraoka, Takeshi× Hamano, Tsuyoshi× Fushiki, Shinji× Ogiu, Toshiaki× 大町 康× 石田 有香× 平岡 武× 濱野 毅× 伏木 信次× 荻生 俊昭 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Exposure to radiation during brain development stage cause microcephaly or mental retardation. Although X- and gamma-rays induced cerebral hypoplasia in rodents has been well characterized, little is known about such effects of neutrons. To examine the effects of prenatal exposure to neutrons on the brain and other organs development, B6C3F1 mice both sexes were irradiated with fast neutrons (0.1, 0.2, 0.5, 1Gy) or gamma-rays (0.8, 1.5Gy) at embryonic day 13.5, and the animals were examined histopathologically 56 days after birth. Both types of radiation mainly caused hypoplasia of the cerebral cortex and lowered brain absolute weight. No sex differences were seen. These changes were remarkable in each highest dose group. The weight loss of the brain was noted at the lowest dose group of neutrons. In addition, the weight loss of the thymus, atrophy of the seminiferous tubules, and a decrease in follicles of the ovary were also noted in the higher dose groups of neutrons and gamma-rays. The degrees of these changes were larger for neutrons. | |||||
| 書誌情報 |
Journal of Toxicologic Pathology 巻 17, 号 1, p. 63-68, 発行日 2004 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0914-9198 | |||||
