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Radiation sensitivities of 31 human oesophageal squamous cell carcinoma cell lines
https://repo.qst.go.jp/records/44243
https://repo.qst.go.jp/records/442434f0786e2-53ff-4414-8e6a-fea4ce645140
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-06-13 | |||||
| タイトル | ||||||
| タイトル | Radiation sensitivities of 31 human oesophageal squamous cell carcinoma cell lines | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ban, Sadayuki
× Ban, Sadayuki× Michikawa, Yuichi× Ishikawa, Ken-ichi× Sagara, Masashi× Watanabe, Koji× Shimada, Yutaka× Inazawa, Jouji× Imai, Takashi× 伴 貞幸× 道川 祐市× 石川 顕一× 相良 雅史× 今井 高志 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The purpose of this study was to determine the radiosensitivities of 31 human esophageal squamous cell carcinoma cell lines with a colony-formation assay. A large variation in radiosensitivity existed among 31 cell lines. Such a large variation may partly explain the poor result of radiotherapy for this cancer. One cell line (KYSE190) demonstrated an unusual radiosensitivity. ATM gene in these cells had five missense mutations and ATM protein was truncated or degraded. Inability to phosphorylate Chk2 in the irradiated KYSE190 cells suggests that the ATM protein in these cells had lost its function. The dysfunctional ATM protein may be a main cause of unusual radiosensitivity of KYSE190 cells. Because the donor of these cells was not diagnosed with ataxia telangiectasia, mutations in ATM gene might have occurred during the initiation and progression of cancer. Radiosensitive cancer developed in non-hereditary diseased patients must be a good target for radiotherapy. | |||||
| 書誌情報 |
International Journal of Experimental Pathology 巻 86, p. 231-240, 発行日 2005 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0959-9673 | |||||
