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Lobe-specific changes in zinc levels in the prostate of rats exposed to tributyltin chloride
https://repo.qst.go.jp/records/44214
https://repo.qst.go.jp/records/44214360cfdc0-b213-4458-b95f-6e52fb125f74
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-06-12 | |||||
| タイトル | ||||||
| タイトル | Lobe-specific changes in zinc levels in the prostate of rats exposed to tributyltin chloride | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Homma-Takeda, Shino
× Homma-Takeda, Shino× Nishimura, Yoshikazu× Watanabe, Yoshito× Yukawa, Masae× Ueno, Shunji× 武田 志乃× 西村 義一× 渡辺 嘉人× 湯川 雅枝× 上野 俊治 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The prostate is an accessory sex organ that secretes essential components of semen. High levels of Zn are found both in the prostate and its secretion. In the present study, the effects environmental stress on zinc levels in the prostate were examined in Wister male rats exposed to tributyltin chloride (TBTC), an environmental toxicant, by inductively coupled argon plasma-mass spectrometry (ICP-MS) for determination of Zn concentration in lobe-dissectioned specimens and micro-PIXE analysis for determination of site-specific distribution of Zn in prostatic sections. A single oral administration of TBTC to rats at a dose of 90mumol/kg resulted 14 days later in a decrease in the Zn level in the dorsolateral prostate but not the ventral prostate. The TBTC did not affect the weight of the prostate tissue. Micro-PIXE imaging found Zn both in the lumen and the epithelium of the lateral prostatic tubules. PIXE spot analysis revealed that the epithelium of the control rat contained levels of Zn 4-fold higher than in the lumen and that Zn in the epithelium decreased selectively after TBTC exposure. | |||||
| 書誌情報 |
International Journal of PIXE 巻 15, 号 3/4, p. 131-138, 発行日 2005-12 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0129-0835 | |||||
