WEKO3
アイテム
Cooperative induction of rat mammary cancer by radiation and 1-methyl-1-nitrosourea via the oncogenic pathways involving c-Myc activation and H-ras mutation
https://repo.qst.go.jp/records/44128
https://repo.qst.go.jp/records/441287d219543-4b56-4ba1-bf04-2e8210ea73ff
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-05-31 | |||||
| タイトル | ||||||
| タイトル | Cooperative induction of rat mammary cancer by radiation and 1-methyl-1-nitrosourea via the oncogenic pathways involving c-Myc activation and H-ras mutation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Imaoka, Tatsuhiko
× Imaoka, Tatsuhiko× Nishimura, Mayumi× Teramoto, Ayako× Nishimura, Yukiko× Ootawara, Masami× Osada, Harumi× Kakinuma, Shizuko× Maekawa, Akihiko× Shimada, Yoshiya× 今岡 達彦× 西村 まゆみ× 寺本 彩子× 西村 由希子× 太田原 雅美× 長田 春美× 柿沼 志津子× 島田 義也 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Humans are continually exposed to various environmental carcinogens. Cancers may arise as a result of exposure to carcinogenic chemicals, ionizing radiation or a combination thereof. However, the mechanism of combined carcinogenesis has been only deduced from oncogenic actions of individual agents. Here, we analyzed experimental mammary carcinogenesis caused by a combination of radiation and a chemical carcinogen, 1-methyl-1-nitrosourea (MNU). Seven-week-old female Sprague-Dawley rats were divided into four groups: control, gamma-irradiated (2 Gy), MNU-treated (40 mg/kg, i.p.), and combined treatment of radiation with subsequent MNU after three days. Rats with palpable tumors were sacrificed at 50 weeks of age to collect tumors for histological typing and mutational analysis of the H-ras gene codon 12. The combined treatment induced adenocarcinomas, but not fibroadenomas, more efficiently than radiation or MNU alone. The H-ras mutation was not seen in radiation-induced carcinomas and was specific to MNU-induced carcinomas in individually treated groups. In the combined treatment group, H-ras-mutated, but not non-mutated, tumors were more frequent and developed significantly earlier than in the MNU-treated group. Significantly higher numbers of cells were stained for activated c-Myc protein in -ray- and combined treatment-induced cancers than in MNU-induced cancers. These results indicate that combined exposure to the two carcinogens elicits an unexpected cooperativity in which pre-irradiation enhances mammary carcinogenesis predominantly through the oncogenic pathway involving H-ras, possibly by synergism with c-Myc activation. | |||||
| 書誌情報 |
International Journal of Cancer 巻 115, 号 2, p. 187-193, 発行日 2005-02 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0020-7136 | |||||
