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Localization of Indium-111 in Human Malignant Tumor Xenografts and Control by Chelators
https://repo.qst.go.jp/records/44087
https://repo.qst.go.jp/records/44087597f2251-f6cd-478b-b30e-b9079b92ec75
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-05-22 | |||||
| タイトル | ||||||
| タイトル | Localization of Indium-111 in Human Malignant Tumor Xenografts and Control by Chelators | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Watanabe, Naoyuki
× Watanabe, Naoyuki× Oriuchi, Noboru× Endou, Keigo× Inoue, Tomio× Tanada, Shuji× Murata, Hajime× Sasaki, Yasuhito× et.al× 渡辺 直行× 遠藤 啓吾× 井上 登美夫× 棚田 修二× 村田 啓× 佐々木 康人 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The kinetics of soluble indium-111(111In) in human malignant tumor xenografts and cells was investigated in combination with chelators. Firstly, without chelator, the kinetics of 111In-choride was investigated in vitro and in vivo using four human malignant neuroblastoma SK-N-MC, pulmonary papillary adenocarcinoma NCI-H441, pulmonary squamous cell carcinoma PC9, and colon adenocarcinoma LS180 cells and xenografts. 111In was incorporated into tumor cells in vitro to a maximum level during a 60-min incubation. A maximum level of radioactivity was demonstrated in vivo in four human malignant tumors xenografted into nude mice at 24 h postinjection of 111In-chloride. Secondly, the effect of edetate calcium disodium (CaNa2EDTA) on radioactivity in 111In-labeled tumors xenografts and cells was studied in vitro and in vivo. CaNa2EDTA significantly reduced 111In-activity from the laveled tumor xenografts, whereas it had no affect on hte radioactivity in the labeled cells. Thirdly, the effect of CaNa2EDA on radioactivity in human malignant tumors xenografted into nude mice injected with 111In-chloride was investigated. In one group of mice CaNa2EDTA administered intraperioneally at 1,22,34,46,58, and 70 h after injection of 111In-chloride (postadministration), the localization of 111In at the tumors was significantly decreased at 72 h compared with the control in all four tumor types. In the other group of mice, CaNa2EDTA administered intraperitoneally at 12 and 1 h before injection of 111In-chloride and 1,22,34,46,58, and 70 h postinjection (pre- and postadministration), the radioactivity of tumors was also significantly decreased at 72 h, and the reduction was greater than that with use of postadministration. In a comparative study, CaNa3DTPA had a more powerful effect than CaNa2EDTA. In conclusion, 111In-activity in tumors consists of intracellular and extracellular components, and the extracellular 111In may be cleared by chelators. Pre- and postadministration of CaNa3DTPA could remove 111In-nonspecific localization in tumors when 111In is released from the radiolaveled agents. | |||||
| 書誌情報 |
Nuclear Medicine and Biology 巻 26, 号 7, p. 853-858, 発行日 1999 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0969-8051 | |||||
