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  1. 原著論文

Regulation of radiation-induced protein kinase Cdelta activation in radiation-induced apoptosis differs between radiosensitive and radioresistant mouse thymic lymphoma cell lines

https://repo.qst.go.jp/records/44023
https://repo.qst.go.jp/records/44023
afcf4fe5-77e1-4529-b999-8f34e43d50ee
Item type 学術雑誌論文 / Journal Article(1)
公開日 2006-03-22
タイトル
タイトル Regulation of radiation-induced protein kinase Cdelta activation in radiation-induced apoptosis differs between radiosensitive and radioresistant mouse thymic lymphoma cell lines
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Nakajima, Tetsuo

× Nakajima, Tetsuo

WEKO 437532

Nakajima, Tetsuo

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Yukawa, Osami

× Yukawa, Osami

WEKO 437533

Yukawa, Osami

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Tsuji, Hideo

× Tsuji, Hideo

WEKO 437534

Tsuji, Hideo

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Ohyama, Harumi

× Ohyama, Harumi

WEKO 437535

Ohyama, Harumi

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Bing, Wang

× Bing, Wang

WEKO 437536

Bing, Wang

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Tatsumi, Kouichi

× Tatsumi, Kouichi

WEKO 437537

Tatsumi, Kouichi

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Hayata, Isamu

× Hayata, Isamu

WEKO 437538

Hayata, Isamu

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Inaba, Hiroko

× Inaba, Hiroko

WEKO 437539

Inaba, Hiroko

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中島 徹夫

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WEKO 437540

en 中島 徹夫

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湯川 修身

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WEKO 437541

en 湯川 修身

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辻 秀雄

× 辻 秀雄

WEKO 437542

en 辻 秀雄

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大山 ハルミ

× 大山 ハルミ

WEKO 437543

en 大山 ハルミ

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王 冰

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WEKO 437544

en 王 冰

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巽 紘一

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WEKO 437545

en 巽 紘一

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早田 勇

× 早田 勇

WEKO 437546

en 早田 勇

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稲葉 浩子

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WEKO 437547

en 稲葉 浩子

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抄録
内容記述タイプ Abstract
内容記述 Protein kinase Cd(PKCd) has an important role in radiation-induced apoptosis. The expression and function of PKCd in radiation-induced apoptosis were assessed in a radiation-sensitive mouse thymic lymphoma cell line, 3SBH5, and its radioresistant variant, XR223. Rottlerin, a PKCd-specific inhibitor, completely abolished radiation-induced apoptosis in 3SBH5. Radiation-induced PKCd activation correlated with the degradation of PKCd, indicating that PKCd activation through degradation is involved in radiation-induced apoptosis in radiosensitive 3SBH5. In radioresistant XR223, radiation-induced PKCd activation was lower than that in radiosensitive 3SBH5. Cytosol PKCd levels in 3SBH5 decreased markedly after irradiation, while those in XR223 did not. There was no apparent change after irradiation in the membrane fractions of either cell type. In addition, basal cytosol PKCd levels in XR223 were higher than those in 3SBH5. These results suggest that the radioresistance in XR223 to radiation-induced apoptosis is due to a difference in the regulation of radiation-induced PKCd activation compared to that of 3SBH5. On the other hand, Atm-/- mouse thymic lymphoma cells were more radioresistant to radiation-induced apoptosis than wild-type mouse thymic lymphoma cells. Irradiated wild-type cells, but not Atm-/- cells, had decreased PKCd levels, indicating that the Atm protein is involved in radiation-induced apoptosis through the induction of PKCd degradation. The decreased Atm protein levels induced by treatment with Atm small interference RNA had no effect on radiation-induced apoptosis in 3SBH5 cells. These results suggest that the regulation of radiation-induced PKCd activation, which is distinct from the Atm-mediated cascade, determines radiation sensitivity in radiosensitive 3SBH5 cells.
書誌情報 Fundamental and Molecular Mechanisms of Mutagenesis : A Section of Mutation Research

巻 595, p. 029-036, 発行日 2006-03
ISSN
収録物識別子タイプ ISSN
収録物識別子 0027-5107
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