WEKO3
アイテム
Metabolic activity in skeletal muscles of patients with non-hypoxaemic chronic obstructive pulmonary disease studied by 31P-magnetic resonance spectroscopy.
https://repo.qst.go.jp/records/44022
https://repo.qst.go.jp/records/440222637b4fb-1b79-4c97-af4b-999e750be1fe
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2006-03-16 | |||||
| タイトル | ||||||
| タイトル | Metabolic activity in skeletal muscles of patients with non-hypoxaemic chronic obstructive pulmonary disease studied by 31P-magnetic resonance spectroscopy. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hamaoka, Tomoko
× Hamaoka, Tomoko× Ikehira, Hiroo× Obata, Takayuki× Tanada, Shuji× Sasaki, Yasuhito× et.al× 池平 博夫× 小畠 隆行× 棚田 修二× 佐々木 康人 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Metabolic activity in skeletal muscles of patients with non-hypoxaemic chronic obstructive pulmonary disease studied by (31)P-magnetic resonance spectroscopy HAMAOKA T, TATSUMI K, SAITO Y, ARAI Y, HORIE Y, MASUYAMA S, TANABE N, TAKIGUCHI Y, IKEHIRA H, OBATA T, SASAKI Y, TANADA S, KURIYAMA T. Respirology 2005; 10: 164-170Objective: An alteration of high energy phosphate metabolism in muscles may contribute to exercise intolerance. The objective of this study was to clarify the changes in high energy phosphate metabolites in muscles during exercise in patients with non-hypoxaemic chronic obstructive pulmonary disease (COPD), which influences the impairment of muscle metabolism. Methodology: Calf muscle energy metabolism was studied in eight stable non-hypoxaemic COPD patients and eight control subjects, using (31)P-magnetic resonance spectroscopy (MRS). MRS spectra were acquired at rest, during exercise at two levels of intensity, and during recovery. The control subjects exercised under both normoxic and hypoxic conditions. The intensity of exercise was standardized by the maximal isometric voluntary contraction (MVC) of the calf muscle and the cross-sectional area (CSA) of calf muscle. Results: MVC and CSA were lower in COPD patients. No significant differences in intracellular pH, inorganic phosphate/phosphocreatine ratio or percentage recovery in inorganic phosphate/phosphocreatine ratio were observed between the two groups in muscles at rest, during exercise or during recovery. Conclusions: Muscle metabolites, during exercise standardized by muscle CSA and MVC, did not differ between non-hypoxaemic COPD patients and control subjects. MVC, CSA or both, are assumed to be closely related to muscle metabolism, as no difference in high energy phosphate metabolites was observed for COPD patients compared to control subjects when the load was standardized for MVC and CSA. This suggests that high energy metabolites are consumed to a similar extent in the same muscle volume in non-hypoxaemic COPD patients and control subjects. | |||||
| 書誌情報 |
Respirology 巻 10, 号 2, p. 164-170, 発行日 2005-03 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1323-7799 | |||||
