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Metabolic activities of partially degenerated hypertrophic chondrocytes: gene expression of hyaluronan synthases.
https://repo.qst.go.jp/records/43941
https://repo.qst.go.jp/records/439414023baab-9d8e-46db-94af-de270dc38e42
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-12-19 | |||||
| タイトル | ||||||
| タイトル | Metabolic activities of partially degenerated hypertrophic chondrocytes: gene expression of hyaluronan synthases. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takada, Yuki
× Takada, Yuki× Sakiyama, Hisako× Kuriiwa, Kazuko× Masuda, Riako× Naokazu, Inoue× Nakagawa, Koichi× Itano, Naoki× Saito, Toshiyuki× Kimata, Koji× et.al× 齋藤 俊行 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Ultrastructural aspects of hypertrophic chondrocytes in hamster and mouse epiphysial cartilage were examined in relation to their metabolic activities. With the hypertrophic change, cytoplasmic vacuolization proceeded leaving the partially intact endoplasmic reticulum (ER). In the hypertrophic cells, cytoplasmic hyaluronan was stained with the biotinylated hyaluronan-binding region (b-HABR) of aggrecan, and mRNAs of hyaluronan synthase (Has 1, Has 2 and Has 3) were detected by in situ hybridization. When the epiphysial cartilage was cultured in the presence of 35S, 3H-GlcNAc, 3H-proline or 14C-palmitic acid, vacuolated late hypertrophic chondrocytes were labeled with these radioactive precursors. The evidence indicates that late hypertrophic chondrocytes are metabolically active, which appears to be essential for the enlargement of chondrocytes. | |||||
| 書誌情報 |
Cell and Tissue Research 巻 298, p. 317-325, 発行日 1999-11 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0302-766X | |||||
