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An ERCC5 gene with homology to yeast RAD2 is involved in group G xeroderma pigmentosum.
https://repo.qst.go.jp/records/43935
https://repo.qst.go.jp/records/43935c2cf7178-d51f-40de-baeb-4ad95bfc7f44
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-12-16 | |||||
| タイトル | ||||||
| タイトル | An ERCC5 gene with homology to yeast RAD2 is involved in group G xeroderma pigmentosum. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shiomi, Tadahiro
× Shiomi, Tadahiro× Harada, Yoshinobu× Saito, Toshiyuki× Shiomi, Naoko× Okuno, Yutaka× Yamaizumi, Masaru× 塩見 忠博× 原田 良信× 齋藤 俊行× 塩見 尚子 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We have isolated a human excision repair gene ERCC5 which complements the defect of the mouse UV-sensitive mutant XL216 (rodent complementation group 5). Here we report cDNA cloning of human and mouse ERCC5 genes using an exon containing an ERCC5 fragment as a probe. The ERCC5 cDNA encodes a predicted 133-kDa nuclear protein that shares some homology with the product of the yeast DNA repair gene RAD2. Transfection with mouse ERCC5 cDNA restored normal levels of UV resistance to XL216 cells. Microinjection of ERCC5 cDNA specifically restored the defect of xeroderma pigmentosum group G cells (XP-G) as measured by unscheduled DNA synthesis, and XP-G cells stably transformed with ERCC5 cDNA showed nearly normal UV resistance. | |||||
| 書誌情報 |
DNA Repair 巻 314, p. 167-175, 発行日 1994-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1568-7864 | |||||
