WEKO3
アイテム
A distamycin A-induced fragile site, FRA*E, is located in the region of the hereditary multiple exostoses gene and is not involved in HPV16 DNA integration and amplification.
https://repo.qst.go.jp/records/43919
https://repo.qst.go.jp/records/439198fec7741-1132-4ee4-b6e3-eb95fe27f111
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-12-16 | |||||
| タイトル | ||||||
| タイトル | A distamycin A-induced fragile site, FRA*E, is located in the region of the hereditary multiple exostoses gene and is not involved in HPV16 DNA integration and amplification. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hori, Tadaaki
× Hori, Tadaaki× Seki, Naohiko× Ohira, Miki× Saito, Toshiyuki× Yamauchi, Masatake× Sagara, Masashi× Hayashi, Akiko× Tsuji, Satsuki× Itou, Hiroko× Imai, Takashi× 堀 雅明× 関 直彦× 齋藤 俊行× 山内 正剛× 相良 雅史× 林 昭子× 辻 さつき× 伊藤 綽子× 今井 高志 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The rare fragile site is a specific point on a chromosome that is expressed as an isochromatid gap or break under certain conditions of cell culture and is inherited in a Mendelian codominant fashion. Five folate-sensitive fragile sites were cloned, and the molecular basis of fragile site mutation was shown to be a new class of mutation, called dynamic mutation, resulting from an allelic expansion of (CCG)n repeats. The mechanism responsible for other types of rare fragile sites, i.e., distamycin A-inducible and BrdU-requiring, is unknown, although cytogenetic studies suggested that these fragile sites play a mechanistic role in breakage and recombination and may also be integration and modification sites of foreign viral DNA genomes. A distamycin A-inducible fragile site, FRA8E, is mapped to 8q24.1 in which various loci implicated in genomic instability are located. Here we identified a YAC clone spanning both FRA8E and the hereditary multiple exostosis (EXT1) gene, using fluorescence in situ hybridization (FISH) analysis of a yeast artificial chromosome (YAC) contig. By using P1 clones as probes, the FRA8E locus was further localized to a 400-kb region including the EXT1 gene. Furthermore, the integration and amplification site of human papillomovirus 16 DNA in the ASCC (argyrophil small cell carcinoma) cells were shown not to coincide with FRA8E, but to be involved in an extensively broad genomic region of 8q24.1, including the c-myc gene. | |||||
| 書誌情報 |
Cancer Genetics and Cytogenetics 巻 101, p. 24-34, 発行日 1998-02 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0165-4608 | |||||
